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The Role of Matrix Metalloproteinases (MMPs) and their Proteolytic Degradation of Chemokines in the Lung

Koloze, Mary T.
http://rave.ohiolink.edu/etdc/view?acc_num=case1269959847

Abstract Details

2010, Master of Sciences, Case Western Reserve University, Pathology.
Matrix metalloproteinases (MMPs) are critical for lung homeostasis including routine tissue maintenance, remodeling, and the immune response. Matrix metalloproteinases can also be detrimental to the lung environment when cleaving critical chemokines. Two important MMPs found commonly in lung conditions characterized by inflammation are MMP-2 and MMP-9. In pulmonary alveolar proteinosis (PAP), the lungs are filled with excess surfactant protein and impaired white blood cell recruitment from the periphery even with elevated cytokines and chemokines associated with inflammation. MMP-2 and the chemokine MCP-3 have increased levels of gene and protein expression in PAP. The granulocyte-macrophage colony-stimulating factor knockout (GM-KO) mouse develops PAP-like symptoms by 6-8 weeks of age. The GM-KO mouse also has excessive surfactant protein buildup in its lungs. We hypothesize that the GM-KO mouse should have increased MMP-2 and MCP-3 levels as seen in the human disease PAP. Furthermore, we propose that cleavage of MCP-3 by MMP-2 in the mouse results in an altered cellular differential and reduced inflammatory clearance. Conclusions: The GM-KO has elevated MCP-3 but not MMP levels in the context of a reduced cellular recruitment.
Tracey Bonfield, PhD (Advisor)
James Anderson, MD PhD (Committee Member)
Nicholas Ziats, PhD (Committee Member)
61 p.
Biomedical Research; Immunology; Pathology
matrix metalloproteinases; chemokines; inflammation; lung disease

Recommended Citations

Citations

  • Koloze, M. T. (2010). The Role of Matrix Metalloproteinases (MMPs) and their Proteolytic Degradation of Chemokines in the Lung [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1269959847

    APA Style (7th edition)

  • Koloze, Mary. The Role of Matrix Metalloproteinases (MMPs) and their Proteolytic Degradation of Chemokines in the Lung. 2010. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1269959847.

    MLA Style (8th edition)

  • Koloze, Mary. "The Role of Matrix Metalloproteinases (MMPs) and their Proteolytic Degradation of Chemokines in the Lung." Master's thesis, Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1269959847

    Chicago Manual of Style (17th edition)

case1269959847
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© 2010, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.