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Human β-defensin 3 peptide is increased and redistributed in Crohn’s ileitis

Meisch, Jeffrey P.
http://rave.ohiolink.edu/etdc/view?acc_num=case1270735950

Abstract Details

2010, Master of Sciences, Case Western Reserve University, Pathology.
Epithelial cell-derived antimicrobial peptides (AMPs) maintain a sterile environment in intestinal crypts, limiting colonization and invasion of commensal microbiota. Decreases in AMP expression are proposed to increase the risk for onset of inflammatory bowel disease (IBD). The expression and function of the inducible AMP, hBD-3, remain poorly characterized in the healthy and chronically inflamed IBD intestine. We report that immunoreactive hBD-3 peptide is present in the terminal ileum (TI) and entire length of the colon in healthy subjects, and confocal microscopy reveals it is localized to Paneth cell granules and the apical surface of the epithelium. In the TI of CD patients, hBD-3 peptide is selectively increased 3-fold, hBD-3 mRNA is elevated, and the peptide’s location switches to the basolateral surface of the columnar epithelial cell and is diffusely distributed within the lamina propria. These results implicate a critical role for hBD-3 in maintaining mucosal immune tolerance.
Alan D. Levine, PhD (Advisor)
George Dubyak, PhD (Committee Chair)
Aaron Weinberg, DDS, PhD (Committee Member)
Thomas McCormick, PhD (Committee Member)
Derek Abbott, MD, PhD (Committee Member)
Clive Hamlin, PhD (Committee Member)
35 p.
Inflammatory Bowel Disease; antimicrobial peptides, hBD-3

Recommended Citations

Citations

  • Meisch, J. P. (2010). Human β-defensin 3 peptide is increased and redistributed in Crohn’s ileitis [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1270735950

    APA Style (7th edition)

  • Meisch, Jeffrey. Human β-defensin 3 peptide is increased and redistributed in Crohn’s ileitis. 2010. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1270735950.

    MLA Style (8th edition)

  • Meisch, Jeffrey. "Human β-defensin 3 peptide is increased and redistributed in Crohn’s ileitis." Master's thesis, Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1270735950

    Chicago Manual of Style (17th edition)

case1270735950
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© 2010, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.