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SNP Associations with Tuberculosis Susceptibility in a Ugandan Household Contact Study

Baker, Allison Rees
http://rave.ohiolink.edu/etdc/view?acc_num=case1274893954

Abstract Details

2010, Master of Sciences, Case Western Reserve University, Epidemiology and Biostatistics.
The World Health Organization reports that over 9 million new cases of tuberculosis (TB) are diagnosed each year, killing between 1.6 and 2 million individuals worldwide. TB is an infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb), and reports indicate that only 10% of individuals infected with Mtb actually advance to disease. Genetic linkage and association analyses have established several chromosome regions involved in TB susceptibility. This study examines the association of TB susceptibility with a selection of biologically relevant markers, a chromosome 7 region identified through a previous genome scan, and association with imputed genotypes. Across chromosomes 7 and 20, 564 Ugandan individuals were genotyped at 1,417 SNPs. None of the candidate genes or fine mapping SNPs were found significantly associated with TB susceptibility (P > 0.10). Five imputed SNPs were significant at the P = 0.01 level. Suggested future work includes GWAS and resequencing analyses.
Catherine Stein, PhD (Committee Chair)
Robert Elston, PhD (Committee Member)
Robert Igo, PhD (Committee Member)
Jill Barnholtz-Sloan, PhD (Committee Member)
70 p.
Biostatistics; Epidemiology; Genetics
SNP; TUBERCULOSIS; TB; kb; TB susceptibility; Haplotype; Genes

Recommended Citations

Citations

  • Baker, A. R. (2010). SNP Associations with Tuberculosis Susceptibility in a Ugandan Household Contact Study [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1274893954

    APA Style (7th edition)

  • Baker, Allison. SNP Associations with Tuberculosis Susceptibility in a Ugandan Household Contact Study. 2010. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1274893954.

    MLA Style (8th edition)

  • Baker, Allison. "SNP Associations with Tuberculosis Susceptibility in a Ugandan Household Contact Study." Master's thesis, Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1274893954

    Chicago Manual of Style (17th edition)

case1274893954
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© 2010, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.