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Use of Insulin Sensitizers as a Novel Treatment for Major Depressive Disorder: A Pilot Study of Pioglitazone for Major Depression Accompanied by Abdominal Obesity

Kemp, David E.
http://rave.ohiolink.edu/etdc/view?acc_num=case1275567223

Abstract Details

2010, Master of Sciences, Case Western Reserve University, Clinical Research.
Objective: To evaluate the safety and efficacy of pioglitazone, a thiazolidinedione insulin sensitizer, in the treatment of major depressive disorder. Method: A 12-week, open-label, prospective trial was conducted in 23 subjects experiencing a major depressive episode. Subjects in this study were either insulin resistant as reflected by abdominal obesity or met criteria for metabolic syndrome. Open-label pioglitazone was administered as monotherapy or adjunctively and initiated at 15mg daily. Primary endpoint was change from baseline to Week 12 in the Inventory of Depressive Symptomatology (IDS) total score. Results: Pioglitazone decreased depression symptom severity from a total IDS score of 40.3(7.1) to 17.9(9.2) at week 12 (p<.001) and this improvement was accompanied by a reduction in insulin resistance (p=.001). The most common side effects were headache and dizziness and no patient discontinued due to side effects. Conclusion: Pioglitazone appears to reduce depression severity and improve several markers of cardiometabolic risk, including insulin resistance.
Joseph Calabrese, MD (Committee Chair)
Faramarz Ismail-Beigi, MD, PhD (Committee Member)
Robert Findling, MD (Committee Member)
38 p.
Mental Health
Major depressive disorder; insulin resistance; abdominal obesity; pioglitazone; metabolic syndrome; anxiety

Recommended Citations

Citations

  • Kemp, D. E. (2010). Use of Insulin Sensitizers as a Novel Treatment for Major Depressive Disorder: A Pilot Study of Pioglitazone for Major Depression Accompanied by Abdominal Obesity [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1275567223

    APA Style (7th edition)

  • Kemp, David. Use of Insulin Sensitizers as a Novel Treatment for Major Depressive Disorder: A Pilot Study of Pioglitazone for Major Depression Accompanied by Abdominal Obesity. 2010. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1275567223.

    MLA Style (8th edition)

  • Kemp, David. "Use of Insulin Sensitizers as a Novel Treatment for Major Depressive Disorder: A Pilot Study of Pioglitazone for Major Depression Accompanied by Abdominal Obesity." Master's thesis, Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1275567223

    Chicago Manual of Style (17th edition)

case1275567223
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© 2010, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.