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EFFECT OF RADIATION THERAPY ON SURVIVAL IN PATIENTS WITH RESECTED MERKEL CELL CARCINOMA: A POPULATION-BASED ANALYSIS

Abstract Details

2010, Master of Sciences, Case Western Reserve University, Clinical Research.
Merkel cell carcinoma (MCC) is an uncommon cutaneous malignancy that despite surgical resection, can cause death. The primary purpose of this study was to determine whether patients in the Surveillance, Epidemiology and End Results (SEER) database who received radiation therapy after resection demonstrate improved survival. Univariate, multivariate, Cox proportional hazards models and propensity scoring with matched pair analyses were performed. Factors that were independently associated with the use of radiation therapy included marital status, disease stage and lymph node surgery. Factors associated with both MCC-specific and overall survival included age and disease stage. Propensity scoring and matched pair analysis demonstrated that patients who received radiation therapy had an improved overall survival but not MCC-specific survival. These data suggest that the improvement in overall survival in patients who receive radiation therapy following surgical resection of MCC may be a result of selection bias or unmeasured factors and not radiation therapy.
Barbara Cromer, M.D. (Committee Chair)
Ernest Borden, M.D. (Committee Member)
Jill Barnholtz-Sloan, Ph.D (Advisor)
45 p.

Recommended Citations

Citations

  • Kim, J. (2010). EFFECT OF RADIATION THERAPY ON SURVIVAL IN PATIENTS WITH RESECTED MERKEL CELL CARCINOMA: A POPULATION-BASED ANALYSIS [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1278471897

    APA Style (7th edition)

  • Kim, Julian. EFFECT OF RADIATION THERAPY ON SURVIVAL IN PATIENTS WITH RESECTED MERKEL CELL CARCINOMA: A POPULATION-BASED ANALYSIS. 2010. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1278471897.

    MLA Style (8th edition)

  • Kim, Julian. "EFFECT OF RADIATION THERAPY ON SURVIVAL IN PATIENTS WITH RESECTED MERKEL CELL CARCINOMA: A POPULATION-BASED ANALYSIS." Master's thesis, Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1278471897

    Chicago Manual of Style (17th edition)