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Biomedical Applications Employing Microfabricated Silicon Nanoporous Membranes

Smith, Ross Andrew
http://rave.ohiolink.edu/etdc/view?acc_num=case1278705155

Abstract Details

2010, Doctor of Philosophy, Case Western Reserve University, EECS - Electrical Engineering.
Microfabricated silicon nanoporous membranes (SNM) are a breakthrough technology with potential in biomedical applications that include, but are not limited to, artificial organs, drug delivery, cell encapsulation, and water purification. SNM have a number of highly advantageous characteristics when compared to polymer filters commonly used in such applications, such as increased chemical and mechanical stability. The characteristic of greatest interest, however, is the monodisperse pore size distribution achieved by the sacrificial removal of a highly controlled silicon oxide layer grown by thermal oxidation. The monodisperse pore size distribution allows for a greater level of characterization of pore and membrane behavior than would otherwise be possible. As such, investigations into the transport and electrical properties of SNM as a whole can be interpreted as an aggregate of individual pores. This work explores the electrical properties of the solution-pore interface via the streaming potential. This is followed by investigations of the size-based and charge-based filtration characteristics of the SNM using fluorescently labeled neutral and anionic Ficoll, a polysaccharide with low asymmetry. Finally, SNM are employed in the removal of endotoxin from an aqueous solution, a critical process in the production of medical grade water.
Christian Zorman, PhD (Committee Chair)
Aaron Fleischman, PhD (Committee Co-Chair)
Francis Merat, PhD (Committee Member)
Miklos Gratzl, PhD (Committee Member)
191 p.
Electrical Engineering
MEMS; BioMEMS; Ultrafiltration; Renal Assist Device; Endotoxin; Water Purification; Streaming Potential; Zeta Potential; Silicon Nanoporous Membranes; Charge Based Filtration; Nanofluidics; Microfluidics

Recommended Citations

Citations

  • Smith, R. A. (2010). Biomedical Applications Employing Microfabricated Silicon Nanoporous Membranes [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1278705155

    APA Style (7th edition)

  • Smith, Ross. Biomedical Applications Employing Microfabricated Silicon Nanoporous Membranes. 2010. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1278705155.

    MLA Style (8th edition)

  • Smith, Ross. "Biomedical Applications Employing Microfabricated Silicon Nanoporous Membranes." Doctoral dissertation, Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1278705155

    Chicago Manual of Style (17th edition)

case1278705155
969
© 2010, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.