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Effects of Gamma Irradiation on the Damage Processes in Human Trabecular Bone

Ramsey, Daniel S.
http://rave.ohiolink.edu/etdc/view?acc_num=case1279224864

Abstract Details

2010, Master of Sciences (Engineering), Case Western Reserve University, EMC - Mechanical Engineering.
Structurally intact trabecular bone allografts are an attractive tissue choice due to their osteoconductive structure and ability to provide some mechanical stability to the graft site. To prevent disease transmission, allograft bone is subjected to gamma sterilization. Irradiation has been shown to reduce the mechanical properties of cortical bone and change micro-damage accumulation in dense bovine trabecular bone. This study seeks to assess the effect of gamma sterilization on the yield properties of human trabecular bone across a range of bone volume fractions. Cylindrical human trabecular specimens (distal and proximal) irradiated to 29.45kGy were compared with non-irradiated controls. Specimens were compressed to past yield and analyzed using histological sections. Mechanical and histological analysis showed no differences between irradiated and control specimens. This suggests that structurally intact trabecular bone allograft, across a range of volume fractions, does not experience significant degradation in strength, stiffness or damage accumulation following gamma irradiation.
Christopher Hernandez (Advisor)
Claire Rimnac (Committee Member)
Joseph Mansour (Committee Member)
106 p.
Engineering; Mechanics
Trabecular bone; cancellous bone; irradiation; gamma;

Recommended Citations

Citations

  • Ramsey, D. S. (2010). Effects of Gamma Irradiation on the Damage Processes in Human Trabecular Bone [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1279224864

    APA Style (7th edition)

  • Ramsey, Daniel. Effects of Gamma Irradiation on the Damage Processes in Human Trabecular Bone. 2010. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1279224864.

    MLA Style (8th edition)

  • Ramsey, Daniel. "Effects of Gamma Irradiation on the Damage Processes in Human Trabecular Bone." Master's thesis, Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1279224864

    Chicago Manual of Style (17th edition)

case1279224864
780
© 2010, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.