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case1279714872.pdf (3.51 MB)
ETD Abstract Container
Abstract Header
Synchronization of Hypoglossal Motoneurons
Author Info
Fietkiewicz, Chris
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=case1279714872
Abstract Details
Year and Degree
2010, Doctor of Philosophy, Case Western Reserve University, EECS - Computer and Information Sciences.
Abstract
Synchronous activity of neurons arises in contexts as diverse as motor function and cognition as well as pathologies such as epileptic seizures and muscle tremors. Yet the actual mechanisms of synchronization are poorly understood. Most studies have focused on the neurons themselves while using extremely simplistic models of inputs to the neurons. However the properties of the inputs are often as unique as the neurons themselves and are equally important in determining the level of synchrony seen at the outputs. We used a combined experimental and modeling approach to study the effects of endogenous inputs on the synchronization of hypoglossal motoneurons. Using paired intracellular recordings, we show that synchrony is primarily due to the correlation of low-frequency waves of excitatory synaptic inputs. This synchrony is modulated by input variability and can exhibit phase differences as large as 100 milliseconds. Computational modeling with synthetic inputs suggests that output synchrony has a linear relationship with low-frequency input correlation. A network model consisting of multiple neuronal clusters successfully demonstrates the phase relationship observed experimentally.
Committee
Kenneth Loparo, PhD (Committee Chair)
Christopher Wilson, PhD (Committee Member)
Roberto Fernández Galán, PhD (Committee Member)
Mehmet Koyutürk, PhD (Committee Member)
Subject Headings
Biophysics
;
Neurology
Keywords
synchronization hypoglossal motoneuron
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Citations
Fietkiewicz, C. (2010).
Synchronization of Hypoglossal Motoneurons
[Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1279714872
APA Style (7th edition)
Fietkiewicz, Chris.
Synchronization of Hypoglossal Motoneurons.
2010. Case Western Reserve University, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=case1279714872.
MLA Style (8th edition)
Fietkiewicz, Chris. "Synchronization of Hypoglossal Motoneurons." Doctoral dissertation, Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1279714872
Chicago Manual of Style (17th edition)
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Document number:
case1279714872
Download Count:
439
Copyright Info
© 2010, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.