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Synchronization of Hypoglossal Motoneurons

Fietkiewicz, Chris
http://rave.ohiolink.edu/etdc/view?acc_num=case1279714872

Abstract Details

2010, Doctor of Philosophy, Case Western Reserve University, EECS - Computer and Information Sciences.
Synchronous activity of neurons arises in contexts as diverse as motor function and cognition as well as pathologies such as epileptic seizures and muscle tremors. Yet the actual mechanisms of synchronization are poorly understood. Most studies have focused on the neurons themselves while using extremely simplistic models of inputs to the neurons. However the properties of the inputs are often as unique as the neurons themselves and are equally important in determining the level of synchrony seen at the outputs. We used a combined experimental and modeling approach to study the effects of endogenous inputs on the synchronization of hypoglossal motoneurons. Using paired intracellular recordings, we show that synchrony is primarily due to the correlation of low-frequency waves of excitatory synaptic inputs. This synchrony is modulated by input variability and can exhibit phase differences as large as 100 milliseconds. Computational modeling with synthetic inputs suggests that output synchrony has a linear relationship with low-frequency input correlation. A network model consisting of multiple neuronal clusters successfully demonstrates the phase relationship observed experimentally.
Kenneth Loparo, PhD (Committee Chair)
Christopher Wilson, PhD (Committee Member)
Roberto Fernández Galán, PhD (Committee Member)
Mehmet Koyutürk, PhD (Committee Member)
Biophysics; Neurology
synchronization hypoglossal motoneuron

Recommended Citations

Citations

  • Fietkiewicz, C. (2010). Synchronization of Hypoglossal Motoneurons [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1279714872

    APA Style (7th edition)

  • Fietkiewicz, Chris. Synchronization of Hypoglossal Motoneurons. 2010. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1279714872.

    MLA Style (8th edition)

  • Fietkiewicz, Chris. "Synchronization of Hypoglossal Motoneurons." Doctoral dissertation, Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1279714872

    Chicago Manual of Style (17th edition)

case1279714872
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© 2010, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.