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Rapid and Quantitative MRI of Chemical Exchange and Magnetization Transfer

Shah, Tejas Jatin
http://rave.ohiolink.edu/etdc/view?acc_num=case1279943930

Abstract Details

2010, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
Chemical Exchange Saturation Transfer (CEST) and Magnetization Transfer (MT) techniques provide unique and potentially quantitative contrast mechanisms in multiple MRI applications. However, the in vivo implementation of these techniques has been limited by the relatively slow MRI acquisition techniques, especially on high field MRI scanners. A new, rapid CEST-FISP (CEST - Fast Imaging with Steady-state free Precession) technique was developed to provide sensitive CEST contrast in approximately 20 seconds. In this study at 7T with in vitro bovine glycogen samples and initial in vivo results in a rat liver, the CEST-FISP technique was shown to provide equivalent CEST sensitivity in comparison to a conventional CEST spin echo acquisition with a 50-fold reduction in acquisition time. The sensitivity of the CEST-FISP technique was also shown to be dependent on k-space encoding with centric k-space encoding providing a 30-40% increase in CEST sensitivity relative to linear encoding for 256 or more k-space lines. Overall, the CEST-FISP acquisition technique provides a rapid and sensitive imaging platform with the potential to provide quantitative CEST and MT imaging data.
Christopher Flask (Advisor)
Mark Griswold (Committee Member)
Xin Yu (Committee Member)
42 p.
Health Care
CEST; MRI; Pulse Sequence

Recommended Citations

Citations

  • Shah, T. J. (2010). Rapid and Quantitative MRI of Chemical Exchange and Magnetization Transfer [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1279943930

    APA Style (7th edition)

  • Shah, Tejas. Rapid and Quantitative MRI of Chemical Exchange and Magnetization Transfer. 2010. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1279943930.

    MLA Style (8th edition)

  • Shah, Tejas. "Rapid and Quantitative MRI of Chemical Exchange and Magnetization Transfer." Master's thesis, Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1279943930

    Chicago Manual of Style (17th edition)

case1279943930
1,105
© 2010, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.