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Spontaneous Calcium Oscillations During Diastole in the Whole Heart: The Influence of Ryanodine Reception Function and Gap Junction Coupling

Plummer, Bradley N.
http://rave.ohiolink.edu/etdc/view?acc_num=case1291050320

Abstract Details

2010, Master of Sciences, Case Western Reserve University, Biomedical Engineering.
Cardiac arrhythmias due to spontaneous diastolic calcium oscillations have been demonstrated in a variety of pathologies; however, their cellular mechanisms in the whole heart are not clear. We hypothesize that calcium oscillations during diastole in the whole heart are due to calcium release from the sarcoplasmic reticulum (SR) and are facilitated by calcium diffusion between neighboring cells. We show that diastolic calcium oscillations in the whole heart are caused by calcium release from the SR and can be enhanced or reduced by increasing and decreasing, respectively, the probability of SR calcium release. In addition, enhancing the probability of SR calcium release synchronized the timing of calcium oscillations across the heart. Surprisingly, decreased cell-to-cell coupling did not block or reduce diastolic calcium oscillations, suggesting their mechanism is governed by regional intrinsic tissue properties. These findings may provide new insight on the mechanisms of cardiac arrhythmias caused by spontaneous diastolic calcium oscillations.
Gustafson Kenneth, PhD (Committee Chair)
Laurita Kenneth, PhD (Committee Member)
Deschenes Isabelle, PhD (Committee Member)
29 p.
Biomedical Engineering; Medicine; Physiology
Spontaneous calcium release; delayed afterdepolarization; triggered arrhythmias

Recommended Citations

Citations

  • Plummer, B. N. (2010). Spontaneous Calcium Oscillations During Diastole in the Whole Heart: The Influence of Ryanodine Reception Function and Gap Junction Coupling [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1291050320

    APA Style (7th edition)

  • Plummer, Bradley. Spontaneous Calcium Oscillations During Diastole in the Whole Heart: The Influence of Ryanodine Reception Function and Gap Junction Coupling. 2010. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1291050320.

    MLA Style (8th edition)

  • Plummer, Bradley. "Spontaneous Calcium Oscillations During Diastole in the Whole Heart: The Influence of Ryanodine Reception Function and Gap Junction Coupling." Master's thesis, Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1291050320

    Chicago Manual of Style (17th edition)

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© 2010, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.