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Measures of Individual Resorption Cavities in Three-Dimensional Images in Cancellous Bone

Tkachenko, Evgeniy
http://rave.ohiolink.edu/etdc/view?acc_num=case1301413780

Abstract Details

2011, Master of Sciences (Engineering), Case Western Reserve University, EMC - Mechanical Engineering.
Resorption cavities result from the activity of osteoclasts, cells that remove old or damaged tissue during bone remodeling. These cavities are believed to act as stress risers, potentially impairing bone strength and increasing fracture risk. Estrogen depletion has been associated with an increase in bone remodeling, but it is unclear whether the change is due to an increase in the number of cavities, surface area of individual cavities, or both. The distribution of stress concentration due to cavities may be related to their number and size, independent of the amount of bone remodeling. Here we present and validate the first, 3D approach to measuring individual resorption cavities in cancellous bone. Additionally, cavity number and surface area are compared in a standard animal model of post-menopausal osteoporosis, the ovarietomized rat.
Christopher Hernandez, PhD (Committee Chair)
Clare Rimnac, PhD (Committee Member)
Joseph Mansour, PhD (Committee Member)
79 p.
Biochemistry; Biology; Biomechanics; Biomedical Engineering; Biomedical Research; Cellular Biology; Health Care; Mechanical Engineering; Mechanics; Medical Imaging; Molecular Biology
Resorption cavities; osteoporosis; biomedical imaging; bone strength; bone remodeling; 3D bone histomorphometry

Recommended Citations

Citations

  • Tkachenko, E. (2011). Measures of Individual Resorption Cavities in Three-Dimensional Images in Cancellous Bone [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1301413780

    APA Style (7th edition)

  • Tkachenko, Evgeniy. Measures of Individual Resorption Cavities in Three-Dimensional Images in Cancellous Bone. 2011. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1301413780.

    MLA Style (8th edition)

  • Tkachenko, Evgeniy. "Measures of Individual Resorption Cavities in Three-Dimensional Images in Cancellous Bone." Master's thesis, Case Western Reserve University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1301413780

    Chicago Manual of Style (17th edition)

case1301413780
516
© 2011, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.