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Mechanobiological Investigation of Periosteum Through Finite Element Modeling and Histology

Miller, Robert M.
http://rave.ohiolink.edu/etdc/view?acc_num=case1307732052

Abstract Details

2011, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
A single stage bone-transport procedure has been shown effective in bridging critical sized diaphyseal bone defects. The procedure harnesses the regenerative potential of the periosteum to infill defects fully with woven bone within two weeks of surgery. In this study, we aim to elucidate the dynamic micromechanical environment of the defect zone. We developed a displacement-driven FE model of the defect, periosteum, and interlocked intramedullary nail in situ, to predict strains and fluid flow within the defect. We hypothesized that areas of greatest mechanically-modulated transport in the defect have significant effects on patterns of de novo bone generation throughout the defect. The FE model was validated using optical strain measurements. This model serves as a preliminary feasibility study for future models to more accurately predict strain, fluid flow, and mass transport within the defect for the study of physical and chemical effects on de novo tissue building by stem cells.
Melissa Knothe Tate, PhD (Committee Chair)
Gerald Saidel, PhD (Committee Member)
Clare Rimnac, PhD (Committee Member)
Biomedical Engineering

Recommended Citations

Citations

  • Miller, R. M. (2011). Mechanobiological Investigation of Periosteum Through Finite Element Modeling and Histology [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1307732052

    APA Style (7th edition)

  • Miller, Robert. Mechanobiological Investigation of Periosteum Through Finite Element Modeling and Histology. 2011. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1307732052.

    MLA Style (8th edition)

  • Miller, Robert. "Mechanobiological Investigation of Periosteum Through Finite Element Modeling and Histology." Master's thesis, Case Western Reserve University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1307732052

    Chicago Manual of Style (17th edition)

case1307732052
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© 2011, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.