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Changes in Peripheral Lipoatrophy, Surrogate Markers of Cardiovascular Disease, and Mitochondria after Rosiglitazone in HIV-infected individuals with Lipoatrophy

Tungsiripat, Marisa

Abstract Details

2011, Master of Sciences, Case Western Reserve University, Clinical Research.

Background: Lipoatrophy, subcutaneous fat wasting, is a stigmatizing complication of antiretroviral therapy (ART). Thiazolidenediones are potent PPARγ agonists and expected to reverse lipoatrophy.

Methods: We evaluated rosiglitazone’s effect on several facets of lipoatrophy: 1) limb fat, 2) surrogate markers cardiovascular disease, and 3) mechanistic measures. We conducted a 48-week randomized, double-blind placebo-controlled trial of rosiglitazone in HIV-infected subjects with lipoatrophy on thymidine nucleoside reverse transcriptase inhibitors (tNRTI)-sparing regimens.

Results: Rosiglitazone significantly (p=0.02) improved peripheral lipoatrophy in the absence of tNRTIs. Carotid intima media thickness (IMT), oxidative, and some inflammatory markers worsened over time in these subjects on stable ART, regardless of the rosiglitazone assignment.

Conclusion: In the absence of tNRTIs, rosiglitazone improved peripheral lipoatrophy. Observed limb fat improvement after rosiglitazone was not associated with changes in surrogate markers of cardiovascular disease or mitochondrial indices. Lipoatrophy can in part be overcome by the PPAR-γ pathway independent of mitochondrial toxicity.

James Spilsbury, PhD (Committee Chair)
Grace McComsey, MD (Committee Member)
Wilson Tang, MD (Committee Member)
45 p.

Recommended Citations

Citations

  • Tungsiripat, M. (2011). Changes in Peripheral Lipoatrophy, Surrogate Markers of Cardiovascular Disease, and Mitochondria after Rosiglitazone in HIV-infected individuals with Lipoatrophy [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1309964773

    APA Style (7th edition)

  • Tungsiripat, Marisa. Changes in Peripheral Lipoatrophy, Surrogate Markers of Cardiovascular Disease, and Mitochondria after Rosiglitazone in HIV-infected individuals with Lipoatrophy. 2011. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1309964773.

    MLA Style (8th edition)

  • Tungsiripat, Marisa. "Changes in Peripheral Lipoatrophy, Surrogate Markers of Cardiovascular Disease, and Mitochondria after Rosiglitazone in HIV-infected individuals with Lipoatrophy." Master's thesis, Case Western Reserve University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1309964773

    Chicago Manual of Style (17th edition)