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case1310138396.pdf (4.99 MB)
ETD Abstract Container
Abstract Header
Affinity-Based Delivery of Retinoids
Author Info
Vesole, Steven Michael
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=case1310138396
Abstract Details
Year and Degree
2011, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
Abstract
Age-related Macular Degeneration (AMD) is a debilitating disease that deteriorates central vision. Retinoid analogues have shown promise in treating AMD and other ocular conditions by circumventing a faulty phototransduction pathway found in unhealthy cells. A cyclodextrin (CD) molecule is a well-known cyclic oligosaccharide that has been used in the food, pharmaceutical, and chemical industries for its unique chemical structure containing a hydrophobic cavity that can increase the solubility of hydrophobic molecules. This hydrophobic interaction, hereby deemed an affinity inclusion complex, is exploited in several hydrogel drug delivery formulations; sustained release was maintained for more than 30 days. Affinity complexes are also explored through spectroscopic analysis, mathematical modeling, and simulation.
Committee
Horst von Recum, PhD (Committee Chair)
Erin Lavik, ScD (Committee Member)
Zheng-Rong Lu, PhD (Committee Member)
Pages
160 p.
Subject Headings
Biomedical Engineering
Keywords
AMD
;
drug delivery
;
cyclodextrin
;
hydrogel
;
retinoid
;
tunable delivery
;
extended delivery
;
ocular delivery
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Citations
Vesole, S. M. (2011).
Affinity-Based Delivery of Retinoids
[Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1310138396
APA Style (7th edition)
Vesole, Steven.
Affinity-Based Delivery of Retinoids.
2011. Case Western Reserve University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=case1310138396.
MLA Style (8th edition)
Vesole, Steven. "Affinity-Based Delivery of Retinoids." Master's thesis, Case Western Reserve University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1310138396
Chicago Manual of Style (17th edition)
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Document number:
case1310138396
Download Count:
1,027
Copyright Info
© 2011, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.