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case1317992169.pdf (4.45 MB)
ETD Abstract Container
Abstract Header
DEVELOPMENT OF NOVEL MOLECULAR IMAGING AGENTS FOR MYELINATION
Author Info
Wang, Changning
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=case1317992169
Abstract Details
Year and Degree
2012, Doctor of Philosophy, Case Western Reserve University, Chemistry.
Abstract
Myelination is one of the fundamental biological processes in the development of the vertebrate nervous system. Disturbance of myelination is found to be associated with progression in many neurological diseases such as multiple sclerosis (MS). Tremendous efforts have been made to develop novel therapeutic agents that prevent demyelination and/or promote remyelination. These efforts need to be accompanied by the development of imaging tools that permit direct quantification of myelination in vivo. In this work, I describe the design, synthesis and evaluation of some novel imaging probes that are capable of direct quantification of myelination in vivo. These probes are now available for further imaging studies that are based on PET, NIRF and PET-NIRF multimodality.
Committee
Yanming Wang, PhD (Advisor)
Irene Lee, PhD (Committee Chair)
Robert Salomon, PhD (Committee Member)
Gregory Tochtrop, PhD (Committee Member)
Robert Miller, PhD (Committee Member)
Pages
168 p.
Subject Headings
Biomedical Research
Keywords
molecular imaging
;
myelin
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Citations
Wang, C. (2012).
DEVELOPMENT OF NOVEL MOLECULAR IMAGING AGENTS FOR MYELINATION
[Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1317992169
APA Style (7th edition)
Wang, Changning.
DEVELOPMENT OF NOVEL MOLECULAR IMAGING AGENTS FOR MYELINATION.
2012. Case Western Reserve University, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=case1317992169.
MLA Style (8th edition)
Wang, Changning. "DEVELOPMENT OF NOVEL MOLECULAR IMAGING AGENTS FOR MYELINATION." Doctoral dissertation, Case Western Reserve University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1317992169
Chicago Manual of Style (17th edition)
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Document number:
case1317992169
Download Count:
868
Copyright Info
© 2011, some rights reserved.
DEVELOPMENT OF NOVEL MOLECULAR IMAGING AGENTS FOR MYELINATION by Changning Wang is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.