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Commercialization of Epineural Conduits for Enhancement of Nerve Regeneration in Segmental Nerve Defects

Goodman, Bryce
http://rave.ohiolink.edu/etdc/view?acc_num=case1340649008

Abstract Details

2012, Master of Sciences, Case Western Reserve University, Biology.
Nerve conduits, allografts, patches, and autografts are commonly used in clinical settings to treat peripheral nerve injuries (PNI) via sutured microsurgery. Injuries caused by trauma such as crush and laceration require regenerative and protective measures. Studies present different outcome profiles reflecting high failure rates and complications associated with autografts and conduits. Proteins naturally expressed by nerve epineurium induce axonal regeneration toward the degenerating stump while providing flexibility and biocompatibility. Harvesting and manufacturing human donor epineural sheath can be cost effective as exhibited by existing partnership agreements and profit margins within the marketplace. This thesis focuses on the development and commercialization of two Cleveland Clinic peripheral nerve repair (PNR) products for surgical use. The applications of both products will address associated high health care costs in the U.S. and efficacy across mid to large nerve gaps. Gap coverage in each the civilian and military market is pending FDA approval.
Christopher Cullis, PhD (Committee Chair)
Hillel Chiel, PhD (Committee Member)
Jean Burns, PhD (Committee Member)
Elizabeth Sump, BS (Committee Member)
90 p.
Biology; Biomedical Engineering; Biomedical Research; Neurobiology
Biotechnology; peripheral nervous system; PNS; CNS; venture capital; epineural sheath; nerve epineurium; peripheral nerve repair; nerve regeneration; commercialization; nerve conduit; nerve graft

Recommended Citations

Citations

  • Goodman, B. (2012). Commercialization of Epineural Conduits for Enhancement of Nerve Regeneration in Segmental Nerve Defects [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1340649008

    APA Style (7th edition)

  • Goodman, Bryce. Commercialization of Epineural Conduits for Enhancement of Nerve Regeneration in Segmental Nerve Defects. 2012. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1340649008.

    MLA Style (8th edition)

  • Goodman, Bryce. "Commercialization of Epineural Conduits for Enhancement of Nerve Regeneration in Segmental Nerve Defects." Master's thesis, Case Western Reserve University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1340649008

    Chicago Manual of Style (17th edition)

case1340649008
1,989
© 2012, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.