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Salivary Biomarkers of Acute Stress and Insulin Sensitivity in Nonhuman Primates

Browning, Geoffrey Robinson

Abstract Details

2013, Master of Sciences, Case Western Reserve University, Biology.
Saliva may be a superior matrix for physiologic measurement because it is noninvasive and allows short-term assessment. Salivary alpha-amylase (sAA) is a novel biomarker of stress in humans, has implications with diabetes, and could be a new tool for improving health and welfare in zoo animals. The goals of our study were to 1) validate measures of salivary insulin, cortisol and sAA and 2) explore relationships between these measures. Saliva was collected twice daily for two weeks in gorillas (Gorilla g. gorilla), mangabeys (Cercocebus chrysogaster), red ruffed lemurs (Varecia rubra) and mongoose lemurs (Eulemur mongoz). Hormones were analyzed with enzyme kinetic or immunoassays. Our study validated tools for analyzing alpha-amylase, cortisol, and insulin in saliva for those species. No significant relationship was found between sAA and insulin. Cortisol and sAA were highly correlated in gorillas and trended toward significance in the mangabey, supporting sAA as a stress marker in gorillas.
Dr. Patricia Dennis, DVM, PhD (Advisor)
Dr. Mandi Vick, PhD (Committee Member)
Dr. Chris Kuhar, PhD (Committee Member)
54 p.

Recommended Citations

Citations

  • Browning, G. R. (2013). Salivary Biomarkers of Acute Stress and Insulin Sensitivity in Nonhuman Primates [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1354912347

    APA Style (7th edition)

  • Browning, Geoffrey. Salivary Biomarkers of Acute Stress and Insulin Sensitivity in Nonhuman Primates. 2013. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1354912347.

    MLA Style (8th edition)

  • Browning, Geoffrey. "Salivary Biomarkers of Acute Stress and Insulin Sensitivity in Nonhuman Primates." Master's thesis, Case Western Reserve University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1354912347

    Chicago Manual of Style (17th edition)