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Meghana Gupta Thesis.pdf (4.03 MB)

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Regulation of Dbl Family Guanine Nucleotide Exchange Factors

Gupta, Meghana B
http://rave.ohiolink.edu/etdc/view?acc_num=case1386175561

Abstract Details

2014, Doctor of Philosophy, Case Western Reserve University, Pharmacology.
Mitogenic signals are initiated by the binding of growth factors to their receptors and culminate in a variety of cellular responses including alterations in gene expression, protein synthesis, cytoskeletal rearrangements, and metabolic pathways. Many mitogens exert their effects by stimulating the activity of Guanine Nucleotide Exchange Factors (GEFs), which in turn activate small GTPases of the Rho family (Rho, Rac and Cdc42). Perturbations in the signaling of Rho GTPases and their GEFs are often associated with several types of neurological and malignant diseases. In order to understand better the roles that GEFs play in diseased states, two main studies were conducted: (1) characterization of a novel Dbl-family GEF, Plekhg4 and (2) determination of the molecular mechanisms that regulate the activity of the proto-typical family member, Dbl.
Danny Manor (Advisor)
111 p.
Cellular Biology; Pharmacology

Recommended Citations

Citations

  • Gupta, M. B. (2014). Regulation of Dbl Family Guanine Nucleotide Exchange Factors [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1386175561

    APA Style (7th edition)

  • Gupta, Meghana. Regulation of Dbl Family Guanine Nucleotide Exchange Factors. 2014. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1386175561.

    MLA Style (8th edition)

  • Gupta, Meghana. "Regulation of Dbl Family Guanine Nucleotide Exchange Factors." Doctoral dissertation, Case Western Reserve University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1386175561

    Chicago Manual of Style (17th edition)

case1386175561
419
© 2014, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.