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Technology and Commercial Assessment of a Tissue Regenerating Drug in the Regenerative Medicine Market

Webber, Nicholas R
http://rave.ohiolink.edu/etdc/view?acc_num=case1402249985

Abstract Details

2014, Master of Arts, Case Western Reserve University, Biology.
Sanford "Sandy" Markowitz, MD, PhD, the Markowitz-Ingalls Professor of Cancer at the Case Western Reserve (CWRU) School of Medicine and practicing physician at University Hospitals of Cleveland (UH), is currently developing a first-in-class tissue-regenerating drug (TRD). TRD has the potential to benefit patients across a number of indications including liver surgery, bone marrow transplants, and ulcerative colitis attacks. TRD inhibits 15-prostaglandin dehydrogenase (15-PGDH), a prostaglandin-inhibiting enzyme, and enhances tissue regeneration in various tissue types. TRD is in the preclinical stage of development and the efficacies of each of its indications are being explored in vitro and in vivo by Dr. Markowitz and his team of researchers at CWRU. The purpose of this thesis is to analyze TRD's potential to enhance the standard of care and to navigate the commercial and regulatory landscapes over a variety ofpotential indications.
Christopher Cullis, PhD (Advisor)
Glen Gaughan , PhD (Committee Member)
Arnold Caplan, PhD (Committee Member)
64 p.
Biology
Bone Marrow Transplant; STEP; Liver Resection; Ulcerative Colitis; PGDH; PGDH-15; Prostaglandins; Stem Cells; Regenerative Medicine

Recommended Citations

Citations

  • Webber, N. R. (2014). Technology and Commercial Assessment of a Tissue Regenerating Drug in the Regenerative Medicine Market [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1402249985

    APA Style (7th edition)

  • Webber, Nicholas. Technology and Commercial Assessment of a Tissue Regenerating Drug in the Regenerative Medicine Market. 2014. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1402249985.

    MLA Style (8th edition)

  • Webber, Nicholas. "Technology and Commercial Assessment of a Tissue Regenerating Drug in the Regenerative Medicine Market." Master's thesis, Case Western Reserve University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1402249985

    Chicago Manual of Style (17th edition)

case1402249985
408
© 2014, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.