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OLFACTORY BULB SYNCHRONY: SPATIALLY LOCALIZED COINCIDENT INHIBITION OF MITRAL CELLS BY GABAERGIC MICROCIRCUITS

Schmidt, Loren Janes
http://rave.ohiolink.edu/etdc/view?acc_num=case1404390871

Abstract Details

2014, Doctor of Philosophy, Case Western Reserve University, Neurosciences.
Activity in the mammalian olfactory bulb (OB) has been long known to oscillate in response to olfactory stimulus. Oscillations in neural substrates are thought to represent synchronous activity of underlying neurons. Due to the circuitry and cytoarchitecture of the OB, the primary neurons, mitral cells (MCs), have been long thought to participate in lateral inhibition that would improve contrast during odor sensing. Activating large ensembles of MCs in an acute slice of the OB with serotonin (5-HT) recruited an increase in inhibitory events onto MCs, surprisingly without a concomitant increase in inhibitory cell action potential rates. The increase in MC inhibitory rate was used to probe the lateral extent to which synchronous inhibition can be found amongst MCs. Contrary to what might be expected due to cell morphology, only nearby MCs share coincident inhibition above levels expected by chance. Directly activating MCs’ inhibitory partners, granule cells (GCs), using electrical stimulation evokes synchronous inhibition above chance levels in MC pairs that did not have not have significant synchronous inhibition in 5-HT. Simulating the temporal jitter associated with the cellular processes of neurotransmitter release indicated that both 5-HT and electrical stimulation recruit divergent inhibition from spiking interneurons. Due to differences in the amplitude distribution of inhibitory events between 5-HT and electrical stimulation it is possible that these two conditions recruit distinct populations of 2 inhibitory synapses or interneurons. Driving GCs through NMDA receptors by removing the tonic blockade of Mg2+ caused an increase in inhibitory events on MCs similar to that found with 5-HT. Under this experimental condition synchronous inhibition between MCs was not detectable.
Ben Strowbridge (Advisor)
Roberto Galán (Committee Chair)
Diana Kunze (Committee Member)
Christopher Ford (Committee Member)
125 p.
Neurobiology
synchrony; olfaction; serotonin; neural circuits

Recommended Citations

Citations

  • Schmidt, L. J. (2014). OLFACTORY BULB SYNCHRONY: SPATIALLY LOCALIZED COINCIDENT INHIBITION OF MITRAL CELLS BY GABAERGIC MICROCIRCUITS [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1404390871

    APA Style (7th edition)

  • Schmidt, Loren. OLFACTORY BULB SYNCHRONY: SPATIALLY LOCALIZED COINCIDENT INHIBITION OF MITRAL CELLS BY GABAERGIC MICROCIRCUITS. 2014. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1404390871.

    MLA Style (8th edition)

  • Schmidt, Loren. "OLFACTORY BULB SYNCHRONY: SPATIALLY LOCALIZED COINCIDENT INHIBITION OF MITRAL CELLS BY GABAERGIC MICROCIRCUITS." Doctoral dissertation, Case Western Reserve University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1404390871

    Chicago Manual of Style (17th edition)

case1404390871
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© 2014, some rights reserved.Creative Commons License OLFACTORY BULB SYNCHRONY: SPATIALLY LOCALIZED COINCIDENT INHIBITION OF MITRAL CELLS BY GABAERGIC MICROCIRCUITS by Loren Janes Schmidt is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.