Skip to Main Content
Frequently Asked Questions
Submit an ETD
Global Search Box
Need Help?
Keyword Search
Participating Institutions
Advanced Search
School Logo
Files
File List
CHAPTERS 1-6_revised_Oct16.pdf (944.22 KB)
ETD Abstract Container
Abstract Header
THE PROBABILITY OF SNPS ASSOCIATED WITH A DISEASE
Author Info
zhang, lu
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=case1413540577
Abstract Details
Year and Degree
2015, Doctor of Philosophy, Case Western Reserve University, Epidemiology and Biostatistics.
Abstract
Multiple inferences are widely used in genome-wide association studies, but there are problems existing in family wise error control (FWER). Benjamini & Hochberg (1995) introduced a new point of view to control errors, the false discover rate (FDR), which is the expected ratio of the number of false rejections to the total number of rejections. FDR is conservative when the unknown number of true null hypotheses is less than the total number of hypotheses. To solve this bias, many methods exist to estimate the number of true null hypotheses. In this dissertation, we develop a simple nonparametric empirical model to help select SNPs that are associated with a disease. This model is connected with the theory of the FDR. The distribution of null hypothesis p-values is estimated by the permutation p-values. The distribution of alternative hypothesis p-values is estimated by the distribution of the original p-values after subtracting the proportion of the null hypothesis p-values. Thus the model can produce a useful posterior probability of effect for each individual SNP with a minimum of prior assumptions. For the Wellcome Trust Case Control Consortium (WTCCC) Crohn’s disease dataset, the highest posterior probabilities are consistent with the most significant p-values. For the colon cancer data, the SNPs with the highest posterior probabilities are quite different from the SNPs with the most significant p-values.
Committee
Robert Elston (Advisor)
Sanford Markowitz (Committee Member)
Xiaofeng Zhu (Committee Member)
Nora Nock (Committee Member)
Pages
124 p.
Subject Headings
Biostatistics
Recommended Citations
Refworks
EndNote
RIS
Mendeley
Citations
zhang, L. (2015).
THE PROBABILITY OF SNPS ASSOCIATED WITH A DISEASE
[Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1413540577
APA Style (7th edition)
zhang, lu.
THE PROBABILITY OF SNPS ASSOCIATED WITH A DISEASE.
2015. Case Western Reserve University, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=case1413540577.
MLA Style (8th edition)
zhang, lu. "THE PROBABILITY OF SNPS ASSOCIATED WITH A DISEASE." Doctoral dissertation, Case Western Reserve University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1413540577
Chicago Manual of Style (17th edition)
Abstract Footer
Document number:
case1413540577
Download Count:
249
Copyright Info
© 2014, some rights reserved.
THE PROBABILITY OF SNPS ASSOCIATED WITH A DISEASE by lu zhang is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.