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LIPOSOMAL FORMULATIONS OF ALKYL NITRITES AND THEIR EFFICACY IN NITROSYLATION OF BLOOD

Natarajan, Shyam
http://rave.ohiolink.edu/etdc/view?acc_num=case1417626145

Abstract Details

2015, Master of Sciences, Case Western Reserve University, Biomedical Engineering.
Blood nitrosylation therapy is a topic of recent discussion in the cardiovascular field. Its main concern is with the restoration of S-Nitrosothiols—an important signaling molecule governing oxygen delivery—to hemoglobin. Currently, there exists no simple continuous delivery system that can deliver nitrosylating agents to blood. This study examines the effectiveness of liposomes for delivering nitrosylating agents. Experiments were carried out to test the efficacy of liposomal formulations of two nitrosylating agents: ethyl nitrite and amyl nitrite. We examined the loading characteristics of the liposomes and by treating purified hemoglobin, red blood cells, and whole blood with liposomal formulations, investigated the controlling mechanism for delivery of ethyl and amyl nitrite. Our results show that a dose-dependent loading of the nitrosylating agents can be achieved in the liposomes. Further, while, in general, the liposomal formulations of these drugs were effective in increasing SNO levels of hemoglobin, the blood plasma plays a critical role in controlling the delivery. Overall, these results suggest that the key benefits of liposomes such as long circulating times and in vivo capabilities can be combined to form a powerful nitrosylating agent delivery system for clinical applications.
Harihara Baskaran, Dr. (Advisor)
James Reynolds, Dr. (Committee Member)
Stathis Karathanasis, Dr. (Committee Member)
47 p.
Biomedical Engineering; Biomedical Research; Polymers

Recommended Citations

Citations

  • Natarajan, S. (2015). LIPOSOMAL FORMULATIONS OF ALKYL NITRITES AND THEIR EFFICACY IN NITROSYLATION OF BLOOD [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1417626145

    APA Style (7th edition)

  • Natarajan, Shyam. LIPOSOMAL FORMULATIONS OF ALKYL NITRITES AND THEIR EFFICACY IN NITROSYLATION OF BLOOD . 2015. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1417626145.

    MLA Style (8th edition)

  • Natarajan, Shyam. "LIPOSOMAL FORMULATIONS OF ALKYL NITRITES AND THEIR EFFICACY IN NITROSYLATION OF BLOOD ." Master's thesis, Case Western Reserve University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1417626145

    Chicago Manual of Style (17th edition)

case1417626145
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© 2014, some rights reserved.Creative Commons License LIPOSOMAL FORMULATIONS OF ALKYL NITRITES AND THEIR EFFICACY IN NITROSYLATION OF BLOOD by Shyam Natarajan is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.