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Calcium, Magnesium, and the Metabolic Syndrome in the 2001-2010 NHANES Adult Data Using Regression and Structural Equation Modeling Methods

Moore, Laura Christine
http://rave.ohiolink.edu/etdc/view?acc_num=case1417792558

Abstract Details

2015, Doctor of Philosophy, Case Western Reserve University, Epidemiology and Biostatistics.
Background: Higher dietary intakes of magnesium (Mg) and calcium (Ca), individually, have been associated with decreased risk of the Metabolic Syndrome (MetSyn). Experimental studies suggest that a higher intracellular ratio of Ca to Mg, potentially induced by a diet high in Ca and low in Mg, may lead to insulin resistance and other components of MetSyn. However, no prior epidemiological studies have examined the ratio or combined intake of Ca and Mg on MetSyn. Objective: We evaluated the association between the dietary intake of Ca and Mg, independently and in combination, the Ca:Mg ratio and MetSyn using regression and structural equation modeling (SEM) methods. Design: We evaluated 9,148 adults from the National Health and Nutrition Examination Study (NHANES) 2001-2010 datasets with complete information on relevant nutrient, demographic, anthropometric and biomarker variables. Results: We found an inverse association between the highest versus the lowest quartile of Mg and MetSyn (OR=0.70; 95% CI: 0.57-0.86), which remained significant in females (OR=0.65; 95% CI: 0.47-0.90), non-Hispanic whites (OR=0.73; 95% CI: 0.58-0.93), and adults =50 years old (OR=0.70; 95% CI: 0.54-0.92) after stratification by gender, race and age, respectively. Women meeting the RDA for both Mg and Ca had the greatest reduced risk of MetSyn (OR=0.59; 95% CI: 0.45-0.76). Men with intakes in the highest quartile of Mg (=386 mg/day) and Ca (=1,224 mg/day), which is above the current RDA, had a decreased risk of MetSyn (OR=0.74; 95% CI: 0.59-0.93). The SEM results were generally consistent with regression models in that higher Mg quartiles were inversely associated with MetSyn in women (standardized path: ß=-0.11 ± 0.02; p<0.001) and men (ß=-0.09 ± 0.04; p=0.03). Further, having Ca and Mg in the highest quartile was associated with MetSyn in women (ß=-0.10 ± 0.02; p<0.001) and adults =50 years old (ß=-0.06 ± 0.03; p=0.03). The SEM also revealed the Ca:Mg ratio was positively associated with MetSyn in women (ß=0.06 ± 0.02; p=0.01) and men (ß=0.06 ± 0.02; p=0.03). Conclusions: Our results suggest that women meeting the RDA for both Mg and Ca have a reduced risk of MetSyn but men may require higher intakes to protect against MetSyn.
Nora Nock, Dr. (Committee Chair)
150 p.
Epidemiology; Nutrition
Calcium, Magnesium, Metabolic Syndrome

Recommended Citations

Citations

  • Moore, L. C. (2015). Calcium, Magnesium, and the Metabolic Syndrome in the 2001-2010 NHANES Adult Data Using Regression and Structural Equation Modeling Methods [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1417792558

    APA Style (7th edition)

  • Moore, Laura. Calcium, Magnesium, and the Metabolic Syndrome in the 2001-2010 NHANES Adult Data Using Regression and Structural Equation Modeling Methods . 2015. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1417792558.

    MLA Style (8th edition)

  • Moore, Laura. "Calcium, Magnesium, and the Metabolic Syndrome in the 2001-2010 NHANES Adult Data Using Regression and Structural Equation Modeling Methods ." Doctoral dissertation, Case Western Reserve University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1417792558

    Chicago Manual of Style (17th edition)

case1417792558
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© 2014, some rights reserved.Creative Commons License Calcium, Magnesium, and the Metabolic Syndrome in the 2001-2010 NHANES Adult Data Using Regression and Structural Equation Modeling Methods by Laura Christine Moore is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.