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THE AGING PROCESS OF C. ELEGANS VIEWED THROUGH TIME DEPENDENT PROTEIN EXPRESSION ANALYSIS

Alouani, David James
http://rave.ohiolink.edu/etdc/view?acc_num=case1436393267

Abstract Details

2015, Master of Sciences, Case Western Reserve University, Systems Biology and Bioinformatics.
The main goal of the present effort is to develop a comprehensive computational and statistical framework for analyzing large scale proteomics data and understand the aging process of Caenorhabditis elegans (C.elegans) nematodes based on the age dependent pattern of the protein expression. Modern numerical methods were used for the analysis, including outlier detection, imputation, entropy and feature selection. Protein expression in C. elegans was found to be highly age dependent. Increased expression in younger nematodes was associated with the activation of metabolic pathways. House-keeping processes, such as proteolysis, protein biogenesis and assembly were found to be important at older age. Network entropy was also found to be age dependent for a significant fraction of proteins. Increased protein expression was associated with reduced entropy. Feature selection analysis further showed that proteins linked to metabolic processes are most predictive of the age of C. elegans nematodes, based on their level of expression.
Masaru Miyagi, Dr. (Advisor)
David Lodowski, Dr. (Committee Member)
Gurkan Bebek, Dr. (Committee Member)
89 p.
Aging; Bioinformatics; Biology; Biostatistics; Computer Science

Recommended Citations

Citations

  • Alouani, D. J. (2015). THE AGING PROCESS OF C. ELEGANS VIEWED THROUGH TIME DEPENDENT PROTEIN EXPRESSION ANALYSIS [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1436393267

    APA Style (7th edition)

  • Alouani, David. THE AGING PROCESS OF C. ELEGANS VIEWED THROUGH TIME DEPENDENT PROTEIN EXPRESSION ANALYSIS . 2015. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1436393267.

    MLA Style (8th edition)

  • Alouani, David. "THE AGING PROCESS OF C. ELEGANS VIEWED THROUGH TIME DEPENDENT PROTEIN EXPRESSION ANALYSIS ." Master's thesis, Case Western Reserve University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1436393267

    Chicago Manual of Style (17th edition)

case1436393267
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© 2015, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.