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Thesis _Zhou Final.pdf (3.18 MB)

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DEVELOPE OF ULTRASOUND ELASTOGRAPHY FOR NONDESTRUCTIVE AND NONINVASIVE CHARACTERIZATION OF STIFFER POLYMERIC BIOMATERIALS

Haoyan, Zhou, United States
http://orcid.org/0000-0002-9974-7264
http://rave.ohiolink.edu/etdc/view?acc_num=case1440685144

Abstract Details

2016, Doctor of Philosophy, Case Western Reserve University, Biomedical Engineering.
Significant advancements in biodegradable polymeric materials have been made for numerous applications including tissue engineering, regenerative medicine and drug delivery. The functions of these polymers within each application often rely on controllable polymer degradation and erosion, yet the process has proven difficult to measure in vivo. Traditional methods for investigating polymer erosion and degradation are destructive, hampering accurate longitudinal measurement of the samples in the same subject. To overcome this limitation we have explored the use of ultrasound elastography imaging as a tool to nondestructively measure strain of poly(lactic-co-glycolic acid) (PLGA) phase sensitive in situ forming implants which changes with progressive loss of structural integrity resulting from polymer erosion. In order to better employ this technology, ultrasound elastography imaging was first characterized and validated by comparing to the gold standard unconfined compression testing of PDMS samples with different Young’s moduli. The detection limit as well as detectable difference of this technique were identified. This imaging system was also optimized to scan stiffer polymeric biomaterials. Using this tool, we investigated erosion kinetics of implants comprised of three different PLGA molecular weights in vitro and in vivo. The in vitro environment was created using a novel polyacrylamide based tissue mimicking phantom while the in vivo experiment was performed subcutaneously using a rat abdominal model. A strong linear relationship independent of polymer molecular weight was found between average strain values and erosion values in both the in vitro and in vivo environment. Results support the use of a mechanical stiffness based predicative model for longitudinal monitoring of material erosion and highlight the use of ultrasound elastography as a nondestructive tool for measuring polymer erosion kinetics.
Horst von Recum (Committee Chair)
Agata Exner (Advisor)
Stuart Rowan (Committee Member)
Joseph Mansour (Committee Member)
Anant Madabhushi (Committee Member)
160 p.
Biomedical Engineering; Biomedical Research; Polymers
Noninvasive, Non-destructive, characterization, polymer, biomaterials, ultrasound, elastography, erosion, degradation, PLGA and mechanical

Recommended Citations

Citations

  • Haoyan, United States, Z. (2016). DEVELOPE OF ULTRASOUND ELASTOGRAPHY FOR NONDESTRUCTIVE AND NONINVASIVE CHARACTERIZATION OF STIFFER POLYMERIC BIOMATERIALS [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1440685144

    APA Style (7th edition)

  • Haoyan, United States, Zhou. DEVELOPE OF ULTRASOUND ELASTOGRAPHY FOR NONDESTRUCTIVE AND NONINVASIVE CHARACTERIZATION OF STIFFER POLYMERIC BIOMATERIALS. 2016. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1440685144.

    MLA Style (8th edition)

  • Haoyan, United States, Zhou. "DEVELOPE OF ULTRASOUND ELASTOGRAPHY FOR NONDESTRUCTIVE AND NONINVASIVE CHARACTERIZATION OF STIFFER POLYMERIC BIOMATERIALS." Doctoral dissertation, Case Western Reserve University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1440685144

    Chicago Manual of Style (17th edition)

case1440685144
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This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.