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The Design, Fabrication, and Testing of a Point of Care Device for Diagnosing Sickle Cell Disease and Other Hemoglobin Disorders

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2016, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
Every day, more than 1,000 children are born with sickle cell disease (SCD) in Sub-Saharan Africa. About 50-80% of these children die before the age of five due to lack of diagnosis. Current laboratory methods are too costly and resource-intensive for widespread diagnosis of SCD. The World Health Organization (WHO) has recognized the unmet need for early screening and diagnosis of SCD in newborns, and estimates that 70% of SCD related deaths are preventable with simple, cost-efficient interventions. To address this need, the HemeChip was developed as a point-of-care device for diagnosing SCD. With a finger-prick volume of blood, HemeChip identifies and quantifies hemoglobin types on a strip of cellulose acetate paper that is housed in a micro-engineered chip with a controlled environment and electrical field. The HemeChip results were validated and benchmarked against standard clinical hemoglobin screening methods, such as bench-top electrophoresis and high performance liquid chromatography.
Umut Gurkan, PhD (Advisor)
Kenneth Gustafson, PhD (Committee Chair)
Jane Little, MD (Committee Member)
61 p.

Recommended Citations

Citations

  • Ung, R. (2016). The Design, Fabrication, and Testing of a Point of Care Device for Diagnosing Sickle Cell Disease and Other Hemoglobin Disorders [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1459188452

    APA Style (7th edition)

  • Ung, Ryan. The Design, Fabrication, and Testing of a Point of Care Device for Diagnosing Sickle Cell Disease and Other Hemoglobin Disorders. 2016. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1459188452.

    MLA Style (8th edition)

  • Ung, Ryan. "The Design, Fabrication, and Testing of a Point of Care Device for Diagnosing Sickle Cell Disease and Other Hemoglobin Disorders." Master's thesis, Case Western Reserve University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1459188452

    Chicago Manual of Style (17th edition)