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Seth_Schulte_Thesis.pdf (9.65 MB)

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Analysis of Glucose-6-Phosphate Dehydrogenase in Malagasy Males Through Genetic Sequencing and a Population-specific Genotyping Assay

Schulte, Seth
http://rave.ohiolink.edu/etdc/view?acc_num=case1459352246

Abstract Details

2016, Master of Sciences, Case Western Reserve University, Biology.
G6PDd has long been associated with malaria endemic regions and is believed to serve as protection from severe malaria. Simultaneously, G6PDd also has serious implications in the treatment of Pv hypnozoites as the only drug approved by the WHO, Primaquine, can cause severe hemolytic anemia in G6PDd individuals. Little research has been done to understand G6PDd genotype or phenotype in Madagascar and how this affects the treatment for Pv in infected individuals, resulting in a gap in knowledge. To fill this gap, a standard Point of Care assay was optimized for use in the field and compared to the complete G6PD gene sequence to begin understanding the concordance between genotype and phenotype. Using complete G6PD gene sequences and population-targeted genotyping techniques, there were four documented exonic single nucleotide polymorphisms associated with African, Mediterranean, and Asian origin, no novel were polymorphisms present, and phenotype concordance within five identified haplotypes was performed.
Peter Zimmerman, PhD (Advisor)
Emmitt Jolly, PhD (Committee Member)
Daniel Tisch, PhD (Committee Member)
82 p.
Genetics
Glucose-6-phosphate dehydrogenase; Glucose-6-phosphate dehydrogenase deficiency; G6PD; G6PDd; Primaquine; Madagascar; genetics

Recommended Citations

Citations

  • Schulte, S. (2016). Analysis of Glucose-6-Phosphate Dehydrogenase in Malagasy Males Through Genetic Sequencing and a Population-specific Genotyping Assay [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1459352246

    APA Style (7th edition)

  • Schulte, Seth. Analysis of Glucose-6-Phosphate Dehydrogenase in Malagasy Males Through Genetic Sequencing and a Population-specific Genotyping Assay. 2016. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1459352246.

    MLA Style (8th edition)

  • Schulte, Seth. "Analysis of Glucose-6-Phosphate Dehydrogenase in Malagasy Males Through Genetic Sequencing and a Population-specific Genotyping Assay." Master's thesis, Case Western Reserve University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1459352246

    Chicago Manual of Style (17th edition)

case1459352246
445
© 2016, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.