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Kernan Masters Thesis.pdf (7.36 MB)

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Delivery of Potent Anti-Mitotic Chemotherapeutic Using High Aspect Ratio, Soft Matter Nanoparticles

Kernan, Daniel L
http://rave.ohiolink.edu/etdc/view?acc_num=case1459511762

Abstract Details

2016, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
Non-Hodgkin’s lymphoma, the most common type of blood cancer, has traditionally been treated with chemotherapeutics. The side effects of this treatment regime significantly affect quality of life for patients. As a result, researchers are developing targeted therapies that deliver the drug to the site of disease more efficiently; the mainstream of developments has focused on antibody-drug conjugates. As an alternative, nanoparticle drug therapies have shown great promise enabling drug delivery to sites of disease based on their size, shape and surface engineerability. Viral nanoparticles are biology-derived carriers that are growing in popularity due to their simple genetic and chemical modification, size tunability from spherical to high-aspect ratio, and biocompatibility. These attributes give a wide range of tools for engineers to design therapeutics with specific toxic loads and surface chemistries to efficiently navigate the body. In this thesis, I developed a viral nanoparticle using the nucleoprotein component from the tobacco mosaic virus (TMV) as the carrier for delivery of the anti-mitotic drug valine-citrulline monomethyl auristatin E (vcMMAE). I demonstrate successful synthesis of the formulation, and effective cell killing of Non-Hodgkin’s lymphoma in vitro.
Nicole Steinmetz, Dr. (Committee Chair)
Giuseppe Strangi, Dr. (Committee Member)
Nicole Seiberlich, Dr. (Committee Member)
46 p.
Biomedical Engineering; Biomedical Research
TMV; tobacco mosaic virus; VNP; viral nanoparticle; NHL; Non-Hodgkins lymphoma; lymphoma; in vitro; vcMMAE; IC50; bioconjugation; targeted therapy; cancer; therapeutic; NHS; NHS chemistry; carrier

Recommended Citations

Citations

  • Kernan, D. L. (2016). Delivery of Potent Anti-Mitotic Chemotherapeutic Using High Aspect Ratio, Soft Matter Nanoparticles [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1459511762

    APA Style (7th edition)

  • Kernan, Daniel. Delivery of Potent Anti-Mitotic Chemotherapeutic Using High Aspect Ratio, Soft Matter Nanoparticles. 2016. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1459511762.

    MLA Style (8th edition)

  • Kernan, Daniel. "Delivery of Potent Anti-Mitotic Chemotherapeutic Using High Aspect Ratio, Soft Matter Nanoparticles." Master's thesis, Case Western Reserve University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1459511762

    Chicago Manual of Style (17th edition)

case1459511762
358
© 2016, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.