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MICRO-GAS EXCHANGER FOR OXYGEN TENSION CONTROL IN BIOLOGICAL MICROFLUIDIC SYSTEMS

Kim, Myeongseop
http://orcid.org/0000-0001-9168-2139
http://rave.ohiolink.edu/etdc/view?acc_num=case1462871978

Abstract Details

2016, Master of Sciences, Case Western Reserve University, EMC - Mechanical Engineering.
Oxygen tension is a crucial element in physiologically relevant in vitro systems as cellular functions and behaviors are affected by oxygen tension. Often, hypoxic chambers and workstations, which are inconvenient for the user, have been used to control oxygen tension. The advancement of microfluidics has facilitated development of innovative devices to mimic physiological conditions such as oxygen tension. Soft-lithography-based microfluidic platforms have been widely utilized for their rapid prototyping capabilities and low-cost material requirements. However, these platforms pose critical shortcomings including labor-intensive fabrication processes. To overcome these challenges, a high-throughput, low-cost, single-use, clinically applicable, and easily implementable micro-gas exchanger integrated with a microfluidic chip is developed. With this system, a heterogeneity in individual sickle cell disease (SCD) patients’ response to hypoxia is observed in terms of increase in the number of adhered RBCs compared to normoxia. Furthermore, significant associations between SCD patients’ response to hypoxia and clinical phenotypes are found.
Umut Gurkan (Advisor)
Jane Little (Committee Member)
Ozan Akkus (Committee Member)
83 p.
Mechanical Engineering
microfluidics, sickle cell disease, blood, hypoxia, oxygen tension

Recommended Citations

Citations

  • Kim, M. (2016). MICRO-GAS EXCHANGER FOR OXYGEN TENSION CONTROL IN BIOLOGICAL MICROFLUIDIC SYSTEMS [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1462871978

    APA Style (7th edition)

  • Kim, Myeongseop. MICRO-GAS EXCHANGER FOR OXYGEN TENSION CONTROL IN BIOLOGICAL MICROFLUIDIC SYSTEMS. 2016. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1462871978.

    MLA Style (8th edition)

  • Kim, Myeongseop. "MICRO-GAS EXCHANGER FOR OXYGEN TENSION CONTROL IN BIOLOGICAL MICROFLUIDIC SYSTEMS." Master's thesis, Case Western Reserve University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1462871978

    Chicago Manual of Style (17th edition)

case1462871978
349
© 2016, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.