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Quantitative Treatment Response Characterization In Vivo: Use Cases in Renal and Rectal Cancers

Antunes, Jacob T, Antunes
http://rave.ohiolink.edu/etdc/view?acc_num=case1467987922

Abstract Details

2016, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
Medical imaging has become widespread for evaluating treatment response in vivo by measuring changes in tumor size or contrast uptake. However, the imaging data alone is limited as it does not capture all information needed for a complete characterization of tumoral response to treatment. Recently, the use of image analysis has enabled strategies for more intelligently extracting information from imaging data. However, these strategies have been scarcely used for treatment response evaluation purposes. In this work, we investigate the development of two classes of image analysis called (1) radiomics for early treatment response characterization and (2) radiologypathology fusion. Radiomics will enable the detection of more subtle changes in the tumor environment in vivo early into the treatment regime, and the fusion of radiology and pathology data will allow annotations of treatment effects seen on the pathology specimen to be spatially mapped onto the corresponding imaging.
Anant Madabhushi, Dr. (Advisor)
Pallavi Tiwari, Dr. (Committee Member)
Xin Yu, Dr. (Committee Member)
47 p.
Biomedical Engineering; Biomedical Research; Medical Imaging
Radiomics; treatment response; computerized analysis; PET-MRI; radiology; pathology; co-registration; rectal cancer

Recommended Citations

Citations

  • Antunes, Antunes, J. T. (2016). Quantitative Treatment Response Characterization In Vivo: Use Cases in Renal and Rectal Cancers [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1467987922

    APA Style (7th edition)

  • Antunes, Antunes, Jacob. Quantitative Treatment Response Characterization In Vivo: Use Cases in Renal and Rectal Cancers. 2016. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1467987922.

    MLA Style (8th edition)

  • Antunes, Antunes, Jacob. "Quantitative Treatment Response Characterization In Vivo: Use Cases in Renal and Rectal Cancers." Master's thesis, Case Western Reserve University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1467987922

    Chicago Manual of Style (17th edition)

case1467987922
761
© 2016, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.