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Ivester Master's Thesis.pdf (735.09 KB)

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15-PGDH Inhibition in Reducing Chemotherapy Induced Intestinal Mucositis and Increasing Hematopoietic Stem Cell Transplant Efficiency

Ivester, Clifford
http://rave.ohiolink.edu/etdc/view?acc_num=case1468405171

Abstract Details

, Master of Sciences, Case Western Reserve University, Pathology.
Gastrointestinal (GI) mucositis arises due to complications from clinical treatments associated with a variety of cancer types. Agents that promote protection or healing of these lesions could be beneficial in the clinical setting as they would allow normal issues that arise with mucositis to be avoided. Similarly, many forms of bone marrow cancer often require a hematopoietic stem cell transplant (HSCT) which comes with a host of issues for patients such as risk of infection or development of Graft-versus-Host disease (GVHD), and there is a need to increase the safety of transplants and manage the major side effects associated with them. Prostaglandin PGE2 is a signaling molecule able to both support proliferation of many cell types as well as decrease inflammation. A 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor has been developed (SW033291) which prevents 15-PGDH from degrading prostaglandins causing a stark increase of PGE2 levels in vivo. Here we show that by co-treating mice with both high dose chemotherapy and SW033291, there is a reduction in the severity of mucositis these mice develop when compared to high dose chemotherapy alone. Here we also show that 15-PGDH inhibition also causes increases in HSCT homing efficiency in both autologous and syngeneic transplant types.
Sanford Markowitz (Advisor)
Biology

Recommended Citations

Citations

  • Ivester, C. (n.d.). 15-PGDH Inhibition in Reducing Chemotherapy Induced Intestinal Mucositis and Increasing Hematopoietic Stem Cell Transplant Efficiency [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1468405171

    APA Style (7th edition)

  • Ivester, Clifford. 15-PGDH Inhibition in Reducing Chemotherapy Induced Intestinal Mucositis and Increasing Hematopoietic Stem Cell Transplant Efficiency. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1468405171.

    MLA Style (8th edition)

  • Ivester, Clifford. "15-PGDH Inhibition in Reducing Chemotherapy Induced Intestinal Mucositis and Increasing Hematopoietic Stem Cell Transplant Efficiency." Master's thesis, Case Western Reserve University. Accessed APRIL 24, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=case1468405171

    Chicago Manual of Style (17th edition)

case1468405171
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This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.