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DEVELOPMENT OF NOVEL PULSE SEQUENCES FOR MAGNETIC RESONANCE FINGERPRINTING

Jiang, Yun
http://rave.ohiolink.edu/etdc/view?acc_num=case1480691677961147

Abstract Details

2017, Doctor of Philosophy, Case Western Reserve University, Biomedical Engineering.
Quantification of tissue properties has long been a research goal in Magnetic Resonance Imaging (MRI). However, the long acquisition time of the conventional quantitative method prohibited its adoption in the clinic. The recently proposed Magnetic Resonance Fingerprinting (MRF) is a novel framework that simultaneously quantifies multiple tissue properties using pseudorandom acquisition parameters. It breaks the convention of MRI which acquires a steady- state signal with fixed acquisition parameters, and thus MRF can exploit all degrees of freedom in the pulse sequence design. With nearly unlimited choices of sequence parameters, the thesis explored and presented MRF methods based on the QUick Echo Split NMR technique (QUEST) to reduce the Specific Absorption Rate (SAR), the Fast Imaging with Steady-state Precession (FISP) to improve the performance with off-resonance, the Double Echo Steady-state (DESS) to quantify diffusion, and a Simultaneous MultiSlice (SMS) MRF to further reduce the acquisition time. The development of these novel methods improves the robustness of MRF and have the potential to extend MRF to wide ranges of applications.
Mark Griswold, PhD (Advisor)
Nicole Seiberlich, PhD (Committee Chair)
Xin Yu, PhD (Committee Member)
Erkki Somersalo, PhD (Committee Member)
Jeffrey Sunshine, MD,PhD (Committee Member)
152 p.
Biomedical Engineering
Magnetic Resonance Imaging; Magnetic Resonance Fingerprinting; T1; T2; relaxation; MRI; MRF

Recommended Citations

Citations

  • Jiang, Y. (2017). DEVELOPMENT OF NOVEL PULSE SEQUENCES FOR MAGNETIC RESONANCE FINGERPRINTING [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1480691677961147

    APA Style (7th edition)

  • Jiang, Yun. DEVELOPMENT OF NOVEL PULSE SEQUENCES FOR MAGNETIC RESONANCE FINGERPRINTING. 2017. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1480691677961147.

    MLA Style (8th edition)

  • Jiang, Yun. "DEVELOPMENT OF NOVEL PULSE SEQUENCES FOR MAGNETIC RESONANCE FINGERPRINTING." Doctoral dissertation, Case Western Reserve University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1480691677961147

    Chicago Manual of Style (17th edition)

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© 2017, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.