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POLYMERIC NANOFIBER/ANTIMICROBIAL FORMULATIONS USING A NOVEL CO-EXTRUSION APPROACH COMPARED WITH ELECTROSPINNING FOR TRANSDERMAL DRUG DELIVERY APPLICATIONS

Abstract Details

2016, Doctor of Philosophy, Case Western Reserve University, Macromolecular Science and Engineering.
The primary objective of the present work was to compare polymeric nanofibers fabricated using a novel co-extrusion technique and electrospining process for development of transdermal patches which can be used for drug administration. Drug loaded transdermal patches are gaining prominence not only because of their non-invasiveness but also due to their lower toxicity compared with other transdermal drug delivery systems. The high surface to volume ratio and microporous structure of polymeric patches make them a good candidate for transdermal delivery systems to compete with products currently available on the market. Also, the possibility of large scale production combined with the simplicity of the co-extrusion process make this technique very attractive for commercialization. We report the successful implementation of a novel melt co-extrusion process to fabricate fibers of poly(caprolactone) (PCL) containing the antifungal compound clotrimazole in different concentrations. The process involves co-extrusion of a drug-loaded PCL along with poly(ethylene oxide) (PEO) as a co-feed, with subsequent removal of PEO to isolate PCL-clotrimazole fibers. In-vitro tests of the clotrimazole-containing fibers demonstrated good antifungal activity which was maintained for more than three weeks. Comparative studies were conducted with clotrimazole-containing PCL fibers fabricated by electrospinning. In addition, we report a simple approach for the fabrication of water-stable, metallic silver-containing poly(acrylic acid) (PAA) fibers with potential use as antimicrobial nonwoven mats. PAA fibers were spun from ethanol containing ethylene glycol followed by thermal crosslinking via ester formation. Good activity was demonstrated in-vitro against strains of fungi and bacteria. In addition, we demonstrates the first successful fabrication of poly(Ethylene Vinyl Acetate) (PEVA) fibers using a novel melt co-extrusion process, along with the incorporation of Tetracycline Hydrochloride (TCH) during co-extrusion and assessment of in-vitro antibacterial activity. This new approach already can process significantly greater quantities (~3lbs/hr) of PEVA:TCH fibers compared with similar electrospun systems.
Gary E. Wnek (Advisor)
Mahmoud Ghannoum (Committee Member)
Hatsuo Ishida (Committee Member)
Alexander M. Jamieson (Committee Member)
100 p.

Recommended Citations

Citations

  • Mofidfar, M. (2016). POLYMERIC NANOFIBER/ANTIMICROBIAL FORMULATIONS USING A NOVEL CO-EXTRUSION APPROACH COMPARED WITH ELECTROSPINNING FOR TRANSDERMAL DRUG DELIVERY APPLICATIONS [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1482512576465589

    APA Style (7th edition)

  • Mofidfar, Mohammad. POLYMERIC NANOFIBER/ANTIMICROBIAL FORMULATIONS USING A NOVEL CO-EXTRUSION APPROACH COMPARED WITH ELECTROSPINNING FOR TRANSDERMAL DRUG DELIVERY APPLICATIONS. 2016. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1482512576465589.

    MLA Style (8th edition)

  • Mofidfar, Mohammad. "POLYMERIC NANOFIBER/ANTIMICROBIAL FORMULATIONS USING A NOVEL CO-EXTRUSION APPROACH COMPARED WITH ELECTROSPINNING FOR TRANSDERMAL DRUG DELIVERY APPLICATIONS." Doctoral dissertation, Case Western Reserve University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1482512576465589

    Chicago Manual of Style (17th edition)