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Thesis- Yu final 2.pdf (4.58 MB)

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Bioinformatics Analysis of Vasorin in Gliomas

Yu, Jennifer
http://rave.ohiolink.edu/etdc/view?acc_num=case1484927314447688

Abstract Details

2017, Master of Sciences, Case Western Reserve University, Clinical Research.
Gliomas are primary brain tumors and are challenging to treat. Traditionally, gliomas are characterized by their histologic appearance and grade. Recently, molecular data have complemented histopathologic data and provided new insights on glioma biology and behavior. Vasorin is a transmembrane protein that is commonly overexpressed in glioblastoma, the most aggressive type of glioma. The function of Vasorin is not well understood but involves regulation of apoptosis induced by inflammation or hypoxia and regulation of transforming growth factor-beta (TGF-beta) signaling. The purpose of this study was to use a bioinformatics approach to discern potential roles for Vasorin in glioma biology. Vasorin expression correlated strongly with tumor grade, glioblastoma, IDH wild type gliomas, TERT promoter mutation and unmethylated MGMT promoter. Proteomic analyses revealed potential interactions between Vasorin and developmental programs, including Notch, TGF-beta and homeobox proteins, and IDH1. Additional studies are needed to validate these findings.
Jeremy Rich (Committee Chair)
52 p.
Biology; Medicine
vasorin, glioma, glioblastoma, brain tumor, IDH1, stem cell, glioma stem cell

Recommended Citations

Citations

  • Yu, J. (2017). Bioinformatics Analysis of Vasorin in Gliomas [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1484927314447688

    APA Style (7th edition)

  • Yu, Jennifer. Bioinformatics Analysis of Vasorin in Gliomas. 2017. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1484927314447688.

    MLA Style (8th edition)

  • Yu, Jennifer. "Bioinformatics Analysis of Vasorin in Gliomas." Master's thesis, Case Western Reserve University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1484927314447688

    Chicago Manual of Style (17th edition)

case1484927314447688
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© 2017, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.