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Joshua Miller Master's Thesis.pdf (860.08 KB)

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Investigating the role of Crabp1 in adipose biology

Miller, Joshua E
http://rave.ohiolink.edu/etdc/view?acc_num=case1485970849757665

Abstract Details

2017, Master of Sciences, Case Western Reserve University, Pharmacology.
Dysfunctional regulation of adipose tissue is a key risk factor for a number of diseases such as type 2 diabetes(1). Consequently, understanding the role of specific proteins involved in adipose biology is critical to treatment of these serious illnesses. Administration of the vitamin A metabolite, retinoic acid has been shown to improve insulin responses and protect against diet-induced obesity in several mouse studies(2,3). One of its carrier proteins, CRABP2 has been shown to participate in adipose tissue biology by enhancing retinoic acid-induced transcriptional modulation of target genes(4,5). Due to its role in adipose tissue biology, we hypothesized that CRABP1 may also be involved. Our studies show that CRABP1 is down regulated upon induction of adipocyte differentiation. However, high fat diet feeding depletes CRABP1 from mouse white adipose tissue, suggesting that there may be an interesting link between CRABP1 and fat accumulation in the adipose tissue.
Noa Noy (Advisor)
Ruth Keri (Committee Chair)
Monica Montano (Committee Member)
David Danielpour (Committee Member)
Hua Lou (Committee Member)
41 p.
Biology; Cellular Biology; Pharmacology
CRABP1; adipocytes; adipogenesis; white adipose tissue

Recommended Citations

Citations

  • Miller, J. E. (2017). Investigating the role of Crabp1 in adipose biology [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1485970849757665

    APA Style (7th edition)

  • Miller, Joshua. Investigating the role of Crabp1 in adipose biology . 2017. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1485970849757665.

    MLA Style (8th edition)

  • Miller, Joshua. "Investigating the role of Crabp1 in adipose biology ." Master's thesis, Case Western Reserve University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1485970849757665

    Chicago Manual of Style (17th edition)

case1485970849757665
424
© 2017, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.