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OPTICAL COHERENCE TOMOGRAPHY TO MEASURE EFFECTS OF AUTOLOGOUS MESENCHYMAL STEM CELL TRANSPLANT IN MULTIPLE SCLEROSIS PATIENTS

Rossman, Ian
http://orcid.org/0000-0002-4684-7157
http://rave.ohiolink.edu/etdc/view?acc_num=case1486132609814919

Abstract Details

2017, Master of Sciences, Case Western Reserve University, Clinical Research.
Anterior visual pathway disease affects >50% of multiple sclerosis (MS) patients. Optical coherence tomography (OCT) monitors MS-related retinal degeneration. Retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thinning in MS correlates with clinical and visual disability, and brain atrophy. Mesenchymal stem cells (MSC) are immunomodulatory in MS animal models, targeting inflammatory CNS injury. A recent Cleveland Clinic phase 1 trial demonstrated feasibility/tolerability of autologous MSC transplant in MS patients. My study analyzed GCL and RNFL relationships with clinical, visual, and MRI measures, before and after MSC transplant. MSC transplant affected no differences from baseline to 6 months in GCL or RNFL thickness. Linear mixed effects models predicted significant, but modest GCL thickness increases following MSC transplant. Thus, MSC neuroprotection was indirectly modeled, but not directly measured clinically or radiographically. Future MSC trials in MS should utilize OCT, a sensitive biomarker for neurodegeneration and response to experimental neuroprotective agents.
Robert Fox (Committee Chair)
Jeffrey Cohen (Committee Member)
Robert Bermel (Committee Member)
Daniel Ontaneda (Committee Member)
94 p.
Medicine
Multiple Sclerosis; mesenchymal stem cell; optical coherence tomography; stem cell transplant; phase 1 clinical trial; linear mixed effects model; retinal ganglion cell layer; retinal nerve fiber layer; neuroprotection

Recommended Citations

Citations

  • Rossman, I. (2017). OPTICAL COHERENCE TOMOGRAPHY TO MEASURE EFFECTS OF AUTOLOGOUS MESENCHYMAL STEM CELL TRANSPLANT IN MULTIPLE SCLEROSIS PATIENTS [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1486132609814919

    APA Style (7th edition)

  • Rossman, Ian. OPTICAL COHERENCE TOMOGRAPHY TO MEASURE EFFECTS OF AUTOLOGOUS MESENCHYMAL STEM CELL TRANSPLANT IN MULTIPLE SCLEROSIS PATIENTS . 2017. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1486132609814919.

    MLA Style (8th edition)

  • Rossman, Ian. "OPTICAL COHERENCE TOMOGRAPHY TO MEASURE EFFECTS OF AUTOLOGOUS MESENCHYMAL STEM CELL TRANSPLANT IN MULTIPLE SCLEROSIS PATIENTS ." Master's thesis, Case Western Reserve University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1486132609814919

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.