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Wek, Kristen_Master's Thesis_Final.pdf (1.88 MB)

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Development of Polymeric Therapeutic Nanoparticles: Toward Targeted Delivery and Efficient 19F MRI of Solid Tumors

Wek, Kristen S
http://orcid.org/0000-0002-1323-9884
http://rave.ohiolink.edu/etdc/view?acc_num=case1491168123379844

Abstract Details

2017, Master of Sciences (Engineering), Case Western Reserve University, Macromolecular Science and Engineering.
To improve current chemotherapy treatments, there is a need for non-harmful imaging modalities that can serve to treat and longitudinally monitor patient tumors. Fluorine MRI provides a safe tracer technology that allows recognition of the size and anatomical location of the tumor. Polymeric nanoparticles were designed with an azide termini, high fluorine content for MRI, self-assembly, and minimal toxicity. Copolymers were polymerized using fluorinated and PEG monomers and shown to self-assemble to colloidal nanoparticles for passive tumor targeting. To improve the imaging properties of the nanoparticle, a library of copolymers, with various molecular weights and compositions, were synthesized to compare imaging efficiency. The signal properties remained consistent between the different polymer compositions indicating a need for external modalities that can be conjugated to the azide handle. These studies indicate that development of the polymeric system can be used to improve the theranostic properties for dual 19F MRI tracer and treatment.
Jonathan Pokorski (Advisor)
46 p.
Polymers
Fluorine MRI; drug delivery; micelles; nanoparticle; copolymers; ATRP

Recommended Citations

Citations

  • Wek, K. S. (2017). Development of Polymeric Therapeutic Nanoparticles: Toward Targeted Delivery and Efficient 19F MRI of Solid Tumors [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1491168123379844

    APA Style (7th edition)

  • Wek, Kristen. Development of Polymeric Therapeutic Nanoparticles: Toward Targeted Delivery and Efficient 19F MRI of Solid Tumors. 2017. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1491168123379844.

    MLA Style (8th edition)

  • Wek, Kristen. "Development of Polymeric Therapeutic Nanoparticles: Toward Targeted Delivery and Efficient 19F MRI of Solid Tumors." Master's thesis, Case Western Reserve University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1491168123379844

    Chicago Manual of Style (17th edition)

case1491168123379844
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© 2017, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.