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Siddharth_Nimbalkar_BME_ MS Thesis.pdf (4.15 MB)

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3D PRINTED CHITOSAN: PEGDA SCAFFOLDS FOR AURICULAR CARTILAGE REGENERATION BY STEREOLITHOGRAPHY AT VISIBLE LIGHT RANGE

Nimbalkar, Siddharth V
http://rave.ohiolink.edu/etdc/view?acc_num=case1491308559181272

Abstract Details

2017, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
Hydrogels allow chondrocytes to maintain their morphology and provides an ideal environment for the chondrocytes to produce cartilage. Hydrogels have been widely used in three- dimensional (3D) printing to create scaffold for tissue engineering. There are various methods in additive manufacturing however, for this study we have decided to use stereolithography because of its high accuracy. In this study, we created a new hybrid biocompatible resin using a combination of natural and synthetic polymers (chitosan and polyethylene glycol diacrylate (PEGDA), respectively) by varying feed-ratios and photo-initiator concentration. Ear-shaped hybrid scaffolds were fabricated by a stereolithographic method using a low cost commercially available 3D printer. Hybrid hydrogel mixture of chitosan (50–190 kDa) and PEGDA (575 Da) were mixed at different feed-ratios. The formulations that were made were ideal in terms of mechanical properties and cell viability. However, the lyophilizing the scaffold affected the porosity that resulted in uneven cell adhesion. Therefore, an alternative formulation of Chitosan and PEGDA mixture was created which subsequently improved the scaffold porosity by CAD printing of the scaffold. This is the first report of stereolithographic printing using a commercially available low cost 3D printer hybridizing cell adhesive properties of chitosan with mechanical robustness of PEGDA in scaffolds suitable for regenerative process of the cartilage.
Ozan Akkus (Committee Chair)
Dominique Durand (Committee Member)
Eben Alsberg (Committee Member)
88 p.
Biomedical Engineering; Biomedical Research
Stereolithography, 3D printing, Chitosan, PEGDA, Auricular cartilage, Tissue Engineering

Recommended Citations

Citations

  • Nimbalkar, S. V. (2017). 3D PRINTED CHITOSAN: PEGDA SCAFFOLDS FOR AURICULAR CARTILAGE REGENERATION BY STEREOLITHOGRAPHY AT VISIBLE LIGHT RANGE [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1491308559181272

    APA Style (7th edition)

  • Nimbalkar, Siddharth. 3D PRINTED CHITOSAN: PEGDA SCAFFOLDS FOR AURICULAR CARTILAGE REGENERATION BY STEREOLITHOGRAPHY AT VISIBLE LIGHT RANGE. 2017. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1491308559181272.

    MLA Style (8th edition)

  • Nimbalkar, Siddharth. "3D PRINTED CHITOSAN: PEGDA SCAFFOLDS FOR AURICULAR CARTILAGE REGENERATION BY STEREOLITHOGRAPHY AT VISIBLE LIGHT RANGE." Master's thesis, Case Western Reserve University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1491308559181272

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.