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Partial Volume Quantification Using Magnetic Resonance Fingerprinting

Deshmane, Anagha Vishwas

Abstract Details

2017, Doctor of Philosophy, Case Western Reserve University, Biomedical Engineering.
Magnetic resonance imaging (MRI) is a key clinical tool which allows for imaging of biological tissues with large field-of-view, millimeter resolution, and good soft tissue contrast, without exposing the patient to ionizing radiation. Magnetic Resonance Fingerprinting (MRF) is a quantitative MRI method which pairs pseudorandom magnetization excitations and fast image acquisition with dictionary-based reconstruction for simultaneous mapping of multiple tissue and experimental properties, including T1, T2, and off-resonance, from a single experiment performed within a clinically feasible scan time. MRF signal evolutions vary in shape for different combinations of encoded properties. Like other quantitative MRI methods, MRF maps yield quantitative maps in which properties are averaged over the voxel dimensions. However, in the presence of partial volumes, voxel-averaged properties are insufficient to quantitatively assess tissue characteristics such as the potential presence of pathology. It is therefore necessary to quantify both tissue properties and voxel composition. The uniqueness of signal evolutions emanating from different tissue types in MRF allows for both tissue property mapping as well as quantification of partial volumes from the same measurement. In this dissertation, two approaches to partial volume quantification by MR Fingerprinting (PV-MRF) are quantitatively assessed for accuracy in the presence of artifacts and model errors. Applications of PV-MRF are also explored, including segmentation of pathology, improved synthetic imaging, and absolute quantification of sub-voxel tissue species.
Mark Griswold (Advisor)
Nicole Seiberlich (Committee Chair)
Xin Yu (Committee Member)
Erkki Somersalo (Committee Member)
204 p.

Recommended Citations

Citations

  • Deshmane, A. V. (2017). Partial Volume Quantification Using Magnetic Resonance Fingerprinting [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1491572611420032

    APA Style (7th edition)

  • Deshmane, Anagha. Partial Volume Quantification Using Magnetic Resonance Fingerprinting. 2017. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1491572611420032.

    MLA Style (8th edition)

  • Deshmane, Anagha. "Partial Volume Quantification Using Magnetic Resonance Fingerprinting." Doctoral dissertation, Case Western Reserve University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1491572611420032

    Chicago Manual of Style (17th edition)