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Design and Fabrication of a Highly Flexible Neural Electrode

Zheng, Yang
http://rave.ohiolink.edu/etdc/view?acc_num=case1491600264895472

Abstract Details

2017, Master of Sciences, Case Western Reserve University, Biomedical Engineering.
Implanted neural electrodes require high stiffness to ensure the insertion into the target tissue and to provide connections to multichannel contacts. However, recent studies suggest that the stiffness of the implanted device can significantly influenced the tissue response, and subsequently the chronic performance of the electrode. Current methods to improve flexibility methods include adding biodegradable or biomimetic substrate materials. But adding those materials also raise issues such as remaining material following biodegradation or increasing the electrode neural distance. The goal of thesis is to design a flexible electrode whose dimension and flexibility should be similar to that of a single axon, as well as an effective insertion method that can minimize the neural trauma. To achieve the goal, carbon nanotube yarns were chosen for their high flexibility and biocompatibility. The flexible carbon nanotube yarns were combined with a removable stiff needle such as a tungsten needle for the insertion. The diameter () and flexural rigidity of the designed neural interface () are similar to that of a single axon. This neural interface was implanted into the rat sciatic nerve and could record neural activity for long periods of time. This novel device provides the basis for a platform technology for long term recording of neural signals in small nerves such as those of the autonomic nervous system which so far has not been achieved.
Dominique Durand (Committee Chair)
56 p.
Biomedical Engineering

Recommended Citations

Citations

  • Zheng, Y. (2017). Design and Fabrication of a Highly Flexible Neural Electrode [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1491600264895472

    APA Style (7th edition)

  • Zheng, Yang. Design and Fabrication of a Highly Flexible Neural Electrode. 2017. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1491600264895472.

    MLA Style (8th edition)

  • Zheng, Yang. "Design and Fabrication of a Highly Flexible Neural Electrode." Master's thesis, Case Western Reserve University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1491600264895472

    Chicago Manual of Style (17th edition)

case1491600264895472
531
© 2017, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.