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Tobacco Mosaic Virus Nanocarrier for Restored Cisplatin Efficacy in Platinum-Resistant Ovarian Cancer

Franke, Christina E
http://orcid.org/0000-0001-7712-3285
http://rave.ohiolink.edu/etdc/view?acc_num=case1493810190306879

Abstract Details

2017, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
Platinum resistance in ovarian cancer is the major determinant of disease prognosis. Resistance can first appear at the onset of disease or develop in platinum-sensitive (PS) disease in response to platinum-based chemotherapy. Due to poor response to alternative therapies, there is an urgent clinical need for a new avenue towards treatment of platinum-resistant (PR) ovarian cancer. Improved delivery systems may circumvent such resistant mechanisms and accelerate translation of existing drugs. In this work, I present a novel platform, tobacco mosaic virus (TMV), as a nanocarrier for cisplatin for treatment of PR ovarian cancer. A reliable method for preparation of the TMV-cisplatin conjugate (TMV-cisPt) was optimized and the cisplatin release was characterized. Efficient uptake in cancer cells in vitro was observed within 15 hours, and TMV-cisPt demonstrated superior cytotoxicity in PS and PR cancer cells when compared to free cisplatin. The cytotoxicity in PR cells and overall lower effective dosage requirement makes TMV-cisPt a potentially powerful system for improved ovarian cancer treatment.
Nicole Steinmetz, Ph.D. (Committee Chair)
Horst von Recum, Ph.D. (Committee Member)
Analisa DiFeo, Ph.D. (Committee Member)
Sourabh Shukla, Ph.D. (Committee Member)
Biomedical Engineering; Biomedical Research; Medicine; Molecular Chemistry; Nanoscience; Nanotechnology; Oncology; Pharmaceuticals; Therapy; Virology
nanomedicine; nanoparticle; cancer treatment; ovarian cancer; drug delivery; platinum resistance; cisplatin; viral nanoparticle; VNP; tobacco mosaic virus; TMV

Recommended Citations

Citations

  • Franke, C. E. (2017). Tobacco Mosaic Virus Nanocarrier for Restored Cisplatin Efficacy in Platinum-Resistant Ovarian Cancer [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1493810190306879

    APA Style (7th edition)

  • Franke, Christina. Tobacco Mosaic Virus Nanocarrier for Restored Cisplatin Efficacy in Platinum-Resistant Ovarian Cancer. 2017. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1493810190306879.

    MLA Style (8th edition)

  • Franke, Christina. "Tobacco Mosaic Virus Nanocarrier for Restored Cisplatin Efficacy in Platinum-Resistant Ovarian Cancer." Master's thesis, Case Western Reserve University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1493810190306879

    Chicago Manual of Style (17th edition)

case1493810190306879
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© 2017, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.