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Functional Characteristics of Cancer Driver Genes in Colorectal Cancer

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2017, Master of Sciences, Case Western Reserve University, Clinical Research.
Colorectal Cancer is the third most commonly diagnosed cancer and third leading cause of cancer death in both men and women. Recent studies have led to the discovery of cancer driver genes whose mutations are mostly observed in low frequencies compared to the total number of tumors analyzed, suggesting that mutations in distinct subsets of driver genes are sufficient for tumorigenesis. We hypothesize that comparing the networks by which the driver genes contribute to tumorigenesis can generate more meaningful functional similarities. We develop an algorithm for within-species network similarity quantification. We compare subnetworks corresponding to colorectal cancer driver genes using this tool to group driver genes. We validate our approach with cell line experiments and show we can predict driver gene similarities based on functional similarities. The relationships between driver genes whose mutations lead to similar phenotypic outcomes are best understood through comparison of pathways that are dysregulated.
Masaru MIyagi, Ph.D. (Committee Chair)
Thomas LaFramboise, Ph.D. (Committee Member)
Jennifer Yu, M.D., Ph.D. (Committee Member)
48 p.

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Citations

  • Bebek, G. (2017). Functional Characteristics of Cancer Driver Genes in Colorectal Cancer [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1495012693440067

    APA Style (7th edition)

  • Bebek, Gurkan. Functional Characteristics of Cancer Driver Genes in Colorectal Cancer. 2017. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1495012693440067.

    MLA Style (8th edition)

  • Bebek, Gurkan. "Functional Characteristics of Cancer Driver Genes in Colorectal Cancer." Master's thesis, Case Western Reserve University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1495012693440067

    Chicago Manual of Style (17th edition)