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Targeting Metastatic Breast Cancer Using Dual-Ligand Nanoparticles

He, Felicia Jane
http://orcid.org/0000-0002-8197-1612
http://rave.ohiolink.edu/etdc/view?acc_num=case1499699087340348

Abstract Details

2017, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
The vast majority of breast cancer mortality is due to metastatic disease. This stems from the fact that today’s drug delivery strategies treat metastasis as a monolith, while metastatic lesions display a highly heterogeneous cell population. Cancer cells continuously change the expression of targetable biomarkers over time and space, which results in different metastatic sites being targeted by different ligands. Thus, adapting conventional targeted drug delivery approaches is unlikely to work due to heterogeneity even across adjacent micrometastatic sites. To capture the dynamic nature of metastasis, we developed a dual-ligand nanoparticle by using two different types of ligands targeting EGFR and avß3 integrin. Animal studies showed that the dual-ligand nanoparticles were capable of targeting different metastatic sites within the same animal, which were otherwise missed. Importantly, the dual-ligand nanoparticle facilitated effective delivery of cytotoxic drugs, which yielded significant improvement in event-free survival in mouse models of breast cancer metastasis.
Efstathios Karathanasis, Ph.D. (Committee Chair)
Pubudu Peiris, Ph.D. (Committee Member)
William Schiemann, Ph.D. (Committee Member)
Satish Viswanath, Ph.D. (Committee Member)
50 p.
Biomedical Engineering; Nanotechnology
metastasis; nanoparticle; dual-ligand targeting; breast cancer

Recommended Citations

Citations

  • He, F. J. (2017). Targeting Metastatic Breast Cancer Using Dual-Ligand Nanoparticles [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1499699087340348

    APA Style (7th edition)

  • He, Felicia. Targeting Metastatic Breast Cancer Using Dual-Ligand Nanoparticles. 2017. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1499699087340348.

    MLA Style (8th edition)

  • He, Felicia. "Targeting Metastatic Breast Cancer Using Dual-Ligand Nanoparticles." Master's thesis, Case Western Reserve University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1499699087340348

    Chicago Manual of Style (17th edition)

case1499699087340348
338
© 2017, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.