Skip to Main Content
Frequently Asked Questions
Submit an ETD
Global Search Box
Need Help?
Keyword Search
Participating Institutions
Advanced Search
School Logo
Files
File List
The Commercilazation of a Noval Antithrombotic Drug.pdf (3.06 MB)
ETD Abstract Container
Abstract Header
The Commercilazation of a Noval Antithrombotic Drug
Author Info
Dai, Yuheng
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=case1505303242046038
Abstract Details
Year and Degree
, Master of Sciences, Case Western Reserve University, Biology.
Abstract
Thrombotic events are the main cause of morbidity and mortality in developed countries, and continue to be an important focus for new therapeutic research. A recent study discovered that thymidine phosphorylase (TYMP) - an enzyme initially purified from human platelets - participates in multiple platelet signaling pathways, and regulates platelet activation and thrombosis. Targeting TYMP might be new antithrombotic therapy solutions. This thesis explores the basic science and pathogenesis of thrombosis, diseases associated with thrombosis, TYMP inhibitor tipiracil and its repositioning use for treatment of thrombotic disorders, and continues with a comprehensive analysis of the business development strategies, including intellectual property, addressable market, competition, regulatory, and reimbursement strategies.
Committee
Michael Benard (Committee Chair)
Christopher Cullis (Committee Member)
Leena Chakravarty (Committee Member)
Wei Li (Committee Member)
Pages
95 p.
Subject Headings
Biology
;
Medicine
Keywords
Thymidine phosphorylase, platelet, thrombosis, anti-platelet therapy, commercialization, drug repositioning, drug repurposing
Recommended Citations
Refworks
EndNote
RIS
Mendeley
Citations
Dai, Y. (2017).
The Commercilazation of a Noval Antithrombotic Drug
[Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1505303242046038
APA Style (7th edition)
Dai, Yuheng.
The Commercilazation of a Noval Antithrombotic Drug.
2017. Case Western Reserve University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=case1505303242046038.
MLA Style (8th edition)
Dai, Yuheng. "The Commercilazation of a Noval Antithrombotic Drug." Master's thesis, Case Western Reserve University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1505303242046038
Chicago Manual of Style (17th edition)
Abstract Footer
Document number:
case1505303242046038
Download Count:
306
Copyright Info
© 2017, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.