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Bayesian Causal Mediation Analysis with Multiple Mediators

Gao, Tianming
http://rave.ohiolink.edu/etdc/view?acc_num=case1512649229134385

Abstract Details

, Doctor of Philosophy, Case Western Reserve University, Epidemiology and Biostatistics.
Causal mediation analysis provides investigators insight into how a treatment or exposure can affect an outcome of interest through one or more mediators on causal pathway. When multiple mediators on the pathway are causally ordered, identification of mediation effects on certain causal pathways requires a sensitivity parameter to be specified. A mixed model-based approach is proposed in the Bayesian framework to connect potential outcomes at different treatment levels, and identify mediation effects independent of a sensitivity parameter, for the natural direct and indirect effects on all causal pathways. The method is first proposed for continuous mediators and outcome with possible mediator by treatment interactions, and later extended to handle mixed type of mediators and outcome. Sensitivity analysis is performed for the prior choices in the Bayesian models in simulation study. The proposed Bayesian method is applied to an adolescence dental health study, to see how social economic status can affect dental caries through a sequence of causally ordered mediators in dental visit and oral hygiene index.
Jeffrey Albert (Advisor)
Biostatistics

Recommended Citations

Citations

  • Gao, T. (n.d.). Bayesian Causal Mediation Analysis with Multiple Mediators [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1512649229134385

    APA Style (7th edition)

  • Gao, Tianming. Bayesian Causal Mediation Analysis with Multiple Mediators. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1512649229134385.

    MLA Style (8th edition)

  • Gao, Tianming. "Bayesian Causal Mediation Analysis with Multiple Mediators." Doctoral dissertation, Case Western Reserve University. Accessed APRIL 23, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=case1512649229134385

    Chicago Manual of Style (17th edition)

case1512649229134385
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This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.