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Investigation of Structural Effects on the AC Magnetic Properties of Iron Oxide Nanoparticles

Abenojar, Eric Chua
http://rave.ohiolink.edu/etdc/view?acc_num=case1516187103909374

Abstract Details

2018, Doctor of Philosophy, Case Western Reserve University, Chemistry.
Iron oxide nanoparticles (IONPs) are widely researched due to their unique magnetic properties, biocompatibility, and potential applications as diagnostic and therapeutic agents (e.g. magnetic particle imaging and magnetic hyperthermia). In this thesis, I have investigated the effect of size, shape, and nanoparticle matrix on the alternating current (AC) magnetic field properties of IONPs. Different routes were explored in order to come up with optimized synthetic procedures to prepare nanoparticles with good size monodispersity and controllable shape. The first part of this work focuses on understanding the size dependent AC magnetic hyperthermia response of IONPs when placed in two different matrices (Chapter 2). Monodisperse spherical IONPs with different sizes (10–25 nm) were prepared and placed in solution (where the particles are free to move) and embedded in a polymer matrix (where the particles have restricted mobility). Magnetic hyperthermia measurements were performed on these two systems at varying excitation field strengths (15–60 kA/m) at a fixed frequency (380 kHz) and their AC magnetic heating properties were measured and analyzed. The second part of this work presents the fabrication of a magnetic thermoreversible glycol chitin-based hydrogel nanocomposite loaded with D-amino acids to be used as a potential viable treatment method for biofilm disruption (Chapter 3). This method utilizes the biofilm dispersal activity of D-amino acids and the magnetic hyperthermia properties of IONPs to fully disrupt pre-formed in vitro biofilms formed by the clinically prevalent bacteria, Staphyloccocus aureus (S. aureus). The last part of this thesis focuses on the correlation between magnetic relaxation and magnetic particle imaging (MPI) signal generation. IONP mobility was gradually restricted by embedding the particles in matrices of increasing viscosity (solution, gel, and polymer film). This allows the exploration of MPI signal generation when Brownian relaxation of the nanoparticles is restricted. The complete suppression of Brownian relaxation in the polymer film provides a unique platform for optimizing MPI tracers. In summary, this thesis provides mechanistic insight into the AC magnetic field properties of iron oxide nanoparticles as a function of size and shape using optimized synthetic routes to prepare highly monodisperse nanoparticles with good shape.
Anna Cristina Samia (Advisor)
Geneviève Sauvé (Committee Chair)
Clemens Burda (Committee Member)
Carlos Crespo-Hernández (Committee Member)
João Maia (Committee Member)
148 p.
Chemistry; Nanoscience; Nanotechnology

Recommended Citations

Citations

  • Abenojar, E. C. (2018). Investigation of Structural Effects on the AC Magnetic Properties of Iron Oxide Nanoparticles [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1516187103909374

    APA Style (7th edition)

  • Abenojar, Eric. Investigation of Structural Effects on the AC Magnetic Properties of Iron Oxide Nanoparticles. 2018. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1516187103909374.

    MLA Style (8th edition)

  • Abenojar, Eric. "Investigation of Structural Effects on the AC Magnetic Properties of Iron Oxide Nanoparticles." Doctoral dissertation, Case Western Reserve University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1516187103909374

    Chicago Manual of Style (17th edition)

case1516187103909374
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© 2018, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.