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Novel Carbon-Nanotube Based Neural Interface for Chronic Recording of Glossopharyngeal Nerve Activity

Kostick, Nathan H
http://rave.ohiolink.edu/etdc/view?acc_num=case1517920588275806

Abstract Details

2018, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
Neural recordings have been used to study physiology since the early 1900’s. However, high quality recordings of small autonomic nerves have been limited to acute studies as most state-of-the-art intra-neural interfaces suffer from poor longevity because of mechanical mismatch between the interface and the nerves leading to thick, fibrotic encapsulation which decreases the signal quality. Chronic, extra-neural interfaces record from the surface of the nerve, however, poor signal-tonoise ratios (SNR) exist because of the inherent electrical signal attenuation. Therefore, a novel intra-neural interface was developed using highly flexible carbon nanotube yarns and tested in chronic, rodent autonomic nerve (glossopharyngeal) preparations. Experimental results show, for the first time, it is possible to record chronically for up to 14 weeks while maintaining high SNR to allow neural activity classification. This capability to chronically record from small nerves establishes the potential of this novel interfacing method as a platform technology for physiological studies.
Dominique Durand (Committee Chair)
Horst von Recum (Committee Member)
Nicholas Ziats (Committee Member)
55 p.
Biomedical Engineering
Neural Engineering, Carbon Nano-Tube, Peripheral Nervous System, CNT, CNTY, PNS, Neural Recording, Biomedical Engineering, Neural Interface, Carbon Nano-Tube Yarn, Chronic Recording, GPN, CSN, Glossopharyngeal Nerve, Spike Sorting, Neural Classification

Recommended Citations

Citations

  • Kostick, N. H. (2018). Novel Carbon-Nanotube Based Neural Interface for Chronic Recording of Glossopharyngeal Nerve Activity [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1517920588275806

    APA Style (7th edition)

  • Kostick, Nathan. Novel Carbon-Nanotube Based Neural Interface for Chronic Recording of Glossopharyngeal Nerve Activity. 2018. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1517920588275806.

    MLA Style (8th edition)

  • Kostick, Nathan. "Novel Carbon-Nanotube Based Neural Interface for Chronic Recording of Glossopharyngeal Nerve Activity." Master's thesis, Case Western Reserve University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1517920588275806

    Chicago Manual of Style (17th edition)

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© 2018, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.