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IDENTIFICATION OF MUTATIONAL LANDSCAPES IN AFRICAN AMERICAN TRIPLE-NEGATIVE BREAST CANCER

Kaur, Jaspreet
http://rave.ohiolink.edu/etdc/view?acc_num=case1523652587887506

Abstract Details

2018, Master of Sciences, Case Western Reserve University, Systems Biology and Bioinformatics.
African American women with Triple-Negative Breast Cancer (TNBC) exhibit poor survival rate even after controlling for socioeconomic and treatment variation which indicate presence of intrinsic biological differences contributing to the observed racial disparities. Analysis of somatic mutation profiles of archival Formalin Fixed Paraffin Embedded (FFPE) tumor tissues from discovery dataset of 36 African American TNBC patients compared to publicly available control and validation datasets of 97 European American and 51 African American TNBC samples respectively, from The Cancer Genome Atlas (TCGA), revealed 15 differentially mutated genes across African American (AA) and European American (EA) datasets. However, mutation frequency of known breast cancer driver genes such as TP53 (AA =71% vs EA=75%, p=0.65) and PIK3CA (AA=17% vs EA=12.36%, p=0.56) did not show significant differences between the two ethnicities. Our results indicate the presence of novel genes that could delineate the differences in TNBC outcomes across African American and European American ethnicities.
Vinay Varadan, Ph.D. (Committee Chair)
Kishore Guda, DVM, Ph.D. (Committee Member)
Gurkan Bebek, Ph.D. (Committee Member)
56 p.
Bioinformatics

Recommended Citations

Citations

  • Kaur, J. (2018). IDENTIFICATION OF MUTATIONAL LANDSCAPES IN AFRICAN AMERICAN TRIPLE-NEGATIVE BREAST CANCER [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1523652587887506

    APA Style (7th edition)

  • Kaur, Jaspreet. IDENTIFICATION OF MUTATIONAL LANDSCAPES IN AFRICAN AMERICAN TRIPLE-NEGATIVE BREAST CANCER. 2018. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1523652587887506.

    MLA Style (8th edition)

  • Kaur, Jaspreet. "IDENTIFICATION OF MUTATIONAL LANDSCAPES IN AFRICAN AMERICAN TRIPLE-NEGATIVE BREAST CANCER." Master's thesis, Case Western Reserve University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1523652587887506

    Chicago Manual of Style (17th edition)

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© 2018, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.