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Diana Suciu Thesis Final Edits.pdf (1.77 MB)

ETD Abstract Container

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NEURAL ACTIVITY WITHIN SOLID BREAST TUMORS AND THE IMPLICATIONS ON METASTASIS

Suciu, Diana J
http://rave.ohiolink.edu/etdc/view?acc_num=case1528117273992639

Abstract Details

2018, Master of Engineering, Case Western Reserve University, Biomedical Engineering.
Solid tumors were once believed to lack innervation. However, recent scientific articles indicate that nerve fibers infiltrate primary tumors through axogenesis. Numerous animal model studies have provided a starting point to understand the autonomic nervous system’s influence on breast cancer progression. However, not one of these studies has reported direct recordings and/or quantified the neural activity within the solid breast tumor to ascertain whether these neural fibers are electrically active and if so, what neural signaling patterns are occurring within the solid tumor during its development through metastasis. We have conducted a novel neural recording experiment using 4T1 (triple-negative) breast cancer mouse model, where microwire electrodes are implanted into the solid tumor and chronic recordings and bioluminescence imaging (BLI) is preformed to track the neural activity and tumor growth through metastasis. Experimental results positively identify the recorded activity within the tumor mass as neural. Furthermore, encouraging evidence has emerged that it may be possible to differentiate pre-metastatic vs. metastatic conditions based on overall signaling patterns and a subset of the active neural population. Analysis of the neural activity within the breast cancer tumor has a 180%-400% increase during metastasis, then previous peak activity during tumor growth. This increase in activity can be utilized to create a predictive model for metastasis.
Dominique Durand, PhD (Committee Chair)
Grant McCallum, PhD (Other)
Stathis Karathanasis, PhD (Committee Member)
Mark Cohen, PhD (Committee Member)
56 p.
Biomedical Engineering; Biomedical Research
breast cancer; neural recording; metastasis; metastatic solid tumors; neural activity; vagus nerve; 4T1; D2A1; neural activity during metastasis; lidocaine; nerve stimulation; autonomic nervous system

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Citations

  • Suciu, D. J. (2018). NEURAL ACTIVITY WITHIN SOLID BREAST TUMORS AND THE IMPLICATIONS ON METASTASIS [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1528117273992639

    APA Style (7th edition)

  • Suciu, Diana. NEURAL ACTIVITY WITHIN SOLID BREAST TUMORS AND THE IMPLICATIONS ON METASTASIS. 2018. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1528117273992639.

    MLA Style (8th edition)

  • Suciu, Diana. "NEURAL ACTIVITY WITHIN SOLID BREAST TUMORS AND THE IMPLICATIONS ON METASTASIS." Master's thesis, Case Western Reserve University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1528117273992639

    Chicago Manual of Style (17th edition)

case1528117273992639
268
© 2018, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.