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The Electrophysiological Effect of Low-Frequency Sensory Stimulation in Medically Refractory Epilepsy

Jones, Jaes Christian
http://orcid.org/0000-0001-9338-8427
http://rave.ohiolink.edu/etdc/view?acc_num=case1551894047504194

Abstract Details

2019, Master of Sciences, Case Western Reserve University, Biomedical Engineering.
Low-frequency audio-visual stimulation has been shown to effectively reduce seizures in two animal models of medically refractory epilepsy. As such, low-frequency sensory stimulation (LFSS) may result in decreased epileptogenic activity in patients with MRE. A clinical trial was used to study the effect of LFSS in 6 patients with MRE. Each patient received both LFSS and control stimulation from a non-invasive audio-visual device for 20 minutes. Spike rates were then compared between stimulation, pre-stim, and post-stim periods. Globally, LFSS increased spike rates compared to baseline (116.126% increase, p = 0.005). For analysis of spikes originating from leads within the hypothesized epileptogenic zone, LFSS decreased spike rates compared to baseline (-41.567%, p < 0.001) and controls stimulation did not (-28.365%, p = 0.089). Therefore, LFSS decreases spike frequency in the EZ, indicating likely therapeutic effects with longer stimulation times, a study of which is needed in order to draw definitive conclusions.
Dominique Durand, Ph.D. (Advisor)
Colin Drummond, Ph.D. (Committee Member)
Richard Burgess, M.D. Ph.D. (Committee Member)
Dileep Nair, M.D. (Advisor)
Jorge Gonzalez-Martinez, M.D. Ph.D. (Committee Co-Chair)
76 p.
Biomedical Engineering; Biomedical Research; Engineering; Health Care; Medicine; Neurology; Neurosciences; Surgery
Epilepsy; Neuromodulation; Non-Invasive; Stereoelectroencephalography; Low-Frequency Stimulation; LFS; Low-Frequency Sensory Stimulation; LFSS; Medically Refractory Epilepsy; MRE

Recommended Citations

Citations

  • Jones, J. C. (2019). The Electrophysiological Effect of Low-Frequency Sensory Stimulation in Medically Refractory Epilepsy [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1551894047504194

    APA Style (7th edition)

  • Jones, Jaes. The Electrophysiological Effect of Low-Frequency Sensory Stimulation in Medically Refractory Epilepsy. 2019. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1551894047504194.

    MLA Style (8th edition)

  • Jones, Jaes. "The Electrophysiological Effect of Low-Frequency Sensory Stimulation in Medically Refractory Epilepsy." Master's thesis, Case Western Reserve University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1551894047504194

    Chicago Manual of Style (17th edition)

case1551894047504194
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© 2019, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.